Maria Manich is a research engineer involved in the study of the cell biology and biomechanics of Entamoeba histolytica, a pathogenic amoeba responsible for amoebiasis. Her work focuses on the cellular dynamics of the organism and how it interacts with host tissues. She has contributed to several studies on the subject, notably on the mechanisms of cell motility and cellular responses to mechanical stimuli in the human intestine. Maria uses advanced imaging techniques and computational analysis to explore these interactions.
Recently, she has been participating in deciphering the neuronal code of Hydra vulgaris, a small freshwater cnidarian.
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2024Fibronectin induces a transition from amoeboid to a fan morphology and modifies migration in Entamoeba histolytica., PLoS Pathog 2024 Jul; 20(7): e1012392.
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2023Live Cells Imaging and Comparative Phosphoproteomics Uncover Proteins from the Mechanobiome in Entamoeba histolytica., Int J Mol Sci 2023 May; 24(10): .
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20224D live imaging and computational modeling of a functional gut-on-a-chip evaluate how peristalsis facilitates enteric pathogen invasion., Science advances.
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2022Domain Adapted Multi-task Learning For Segmenting Amoeboid Cells in Microscopy, IEEE Transactions on Medical Imaging, 2022.
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2022PI Kinase-EhGEF2-EhRho5 axis contributes to LPA stimulated macropinocytosis in Entamoeba histolytica, PLoS Pathog 18(5): e1010550.
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2020Zika Virus Inhibits IFN-α Response by Human Plasmacytoid Dendritic Cells and Induces NS1-Dependent Triggering of CD303 (BDCA-2) Signaling, Front Immunol. 2020 Oct 28;11:582061.
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2020A Protocol to Quantify Cellular Morphodynamics: From Cell Labelling to Automatic Image Analysis, Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology, 2020.
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2018Morphodynamics of the Actin-Rich Cytoskeleton in Entamoeba histolytica, Front Cell Infect Microbiol. 2018 May 29;8:179.
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2017BioFlow: a non-invasive, image-based method to measure speed, pressure and forces inside living cells., Sci Rep 2017 08; 7(1): 9178.
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2016Biophysical measurements in 2D and 3D live cell imaging using fluid dynamics and optical flow, 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI), Prague, 2016, pp. 980-983.
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