About Immature neurons in the olfactory bulb My current interests center on (1) the effects of infection and inflammation on olfaction, (2) the role of nasal dysbiosis in Parkinson disease, and (3) the role of adult neurogenesis in olfaction.
Transversal Projects Major Federating Program Microbes & Brain Program general concept Can microbes influence the brain to maintain health or drive pathology? Will our understanding of the microbes and brain connection generate novel therapeutic approaches? The Major Federating Program Microbes & Brain […]
Projects Project Ongoing 2 Members Etude métabolomique de la dysbiose nasale dans la maladie de Parkinson « SMELLPARK-METABOLOME » Françoise Lazarini-Serandour (PI) Sorry, this entry is only available in FR. Project Ongoing 10 Members SMELLPARK. Role of nasal dysbiosis in Parkinson disease Françoise Lazarini-Serandour (PI) Olfactory dysfunction is frequent in Parkinson Disease (PD) and may be present years before the motor symptoms appear. The early olfactory dysfunction could result from environmental factors acting through the nasal cavity such as […] Project Ongoing 7 Members (SOCSET) Studying Olfactory and Cognitive Symptoms Evolution in long-COVID Patients Pierre-Marie Lledo (PI) Sudden loss of smell is a common symptom associated with COVID-19 and SARS-CoV-2 infection of neurons in the olfactory system has been reported in both hamsters and humans. The vast majority of patients with […] Project Ongoing 15 Members Adult neurogenesis and brain plasticity Pierre-Marie Lledo (PI) The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […] Project Completed 5 Members Role of Neuroinflammation in Adult Neurogenesis Françoise Lazarini-Serandour (PI) Neuroinflammation, a specialized immune response that takes place in the central nervous system, has been linked to neurodegenerative diseases. Also, it has been demonstrated to affect important processes in the brain, such […] Project Completed 5 Members Functional consequences of congenital cytomegalovirus infection on the central nervous system Françoise Lazarini-Serandour (PI) Human cytomegalovirus (CMV) is the first cause of congenital malformation resulting from viral infection, and the leading cause of mental retardation and hearing loss. We are assessing the impact of congenital CMV infection on […]
Patents Olfactory means for the diagnosis of neurological complications of nervous system infection The application generally relates to olfaction as a biomarker, more particularly as a prognostic biomarker or biological predictor, of neurosensory disease or disorder and/or of neurocognitive disease or disorder, in subjects whose nervous system […] OLFACTORY MEANS USEFUL IN THE DIAGNOSIS AND TREATMENT OF MOOD DEPRESSION The application relates to the measure of olfactory discrimination capacity in subjects affected by a psychiatric disorder or disease involving mood disturbance, more particularly mood depression. The application provides means that are especially adapted […]
Publications Download 2022 Lazarini F, Lannuzel A, Cabié A, Michel V, Madec Y, Chaumont H, Calmont I, Favrat M, Montagutelli X, Roze E, Lledo PM, Olfactory outcomes in Zika virus-associated Guillain-Barré syndrome., Eur J Neurol 2022 Sep; 29(9): 2823-2831. 2022 Lazarini F, Roze E, Lannuzel A, Lledo PM, , The microbiome-nose-brain axis in health and disease., Trends Neurosci 2022 Aug; (): . 2022 Gransagne M, Aymé G, Brier S, Chauveau-Le Friec G, Meriaux V, Nowakowski M, Dejardin F, Levallois S, Dias de Melo G, Donati F, Prot M, Brûlé S, Raynal B, Bellalou J, Goncalves P, Montagutelli X, Di Santo JP, Lazarini F, England P, Petres S, Escriou N, Lafaye P, , Development of a highly specific and sensitive VHH-based sandwich immunoassay for the detection of the SARS-CoV-2 nucleoprotein., J Biol Chem 2022 Jan; 298(1): 101290. 2022 Lazarini F, Levivien S, Madec Y, Taieb F, Mottez E, Buivan TP, Maudoux A, Wiener-Vacher S, Nevoux J, Van Den Abbeele T, Gressens P, Lledo PM, Teissier N, Olfactory function in congenital cytomegalovirus infection: a prospective study., Eur J Pediatr 2022 May; 181(5): 1859-1869. 2021 de Melo GD, Lazarini F, Larrous F, Feige L, Kornobis E, Levallois S, Marchio A, Kergoat L, Hardy D, Cokelaer T, Pineau P, Lecuit M, Lledo PM, Changeux JP, Bourhy H, , Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin., EMBO Mol Med 2021 Aug; 13(8): e14122. 2021 Robinot R, Hubert M, de Melo GD, Lazarini F, Bruel T, Smith N, Levallois S, Larrous F, Fernandes J, Gellenoncourt S, Rigaud S, Gorgette O, Thouvenot C, Trébeau C, Mallet A, Duménil G, Gobaa S, Etournay R, Lledo PM, Lecuit M, Bourhy H, Duffy D, Michel V, Schwartz O, Chakrabarti LA, SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance., Nat Commun 2021 Jul; 12(1): 4354. 2021 de Melo GD, Lazarini F, Levallois S, Hautefort C, Michel V, Larrous F, Verillaud B, Aparicio C, Wagner S, Gheusi G, Kergoat L, Kornobis E, Donati F, Cokelaer T, Hervochon R, Madec Y, Roze E, Salmon D, Bourhy H, Lecuit M, Lledo PM, , COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters., Sci Transl Med 2021 Jun; 13(596): . 2021 Guedj E, Lazarini F, Morbelli S, Ceccaldi M, Hautefort C, Kas A, Radulesco T, Salmon-Ceron D, Eldin C, , Long COVID and the brain network of Proust’s madeleine: targeting the olfactory pathway., Clin Microbiol Infect 2021 May; (): . 2020 Chaumont H, Roze E, Tressières B, Lazarini F, Lannuzel A, , Central nervous system infections in a tropical area: Influence of emerging and rare infections., Eur. J. Neurol. 2020 Jun; (): . 2019 Lannuzel A, Fergé JL, Lobjois Q, Signate A, Rozé B, Tressières B, Madec Y, Poullain P, Herrmann C, Najioullah F, McGovern E, Savidan AC, Valentino R, Breurec S, Césaire R, Hirsch E, Lledo PM, Thiery G, Cabié A, Lazarini F, Roze E, Long-term outcome in neuroZika: When biological diagnosis matters, Neurology 2019 Apr;. + View full list of publications