I’m a trained biophysicist and develop integrated approaches combining fluorescence imaging, computerized image analysis, and mathematical modeling. Equipped with these skills, I want to contribute to a better quantitative understanding of biological processes. My current focus is on gene expression, however, this integrated approach can be readily applied to other biological questions where imaging and modeling form an integral part to obtain a deeper quantitative understanding.
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Timeline
Projects
Software
CV
EDUCATION
Ph.D.
- Graz University of Technology, Austria and National Institutes of Health (NIH), Bethesda; 2005 – 2008
- Thesis: Quantitative analysis of the dynamic properties of chromatin associated proteins by FRAP experiments
- Advisors: Dr. James G. McNally, Dr. Zlatko Trajanoski
M.S.
- Computational Physics, Universität Graz, Austria, 1999 – 2005
- Thesis: Numerical Simulations of FRAP Experiments
- Advisors: Dr. Max Lippitsch, Dr. Zlatko Trajanoski
Publications
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2022Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH., Life Sci Alliance 2022 04; 5(4): .
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2022FISH-quant v2: a scalable and modular tool for smFISH image analysis., RNA 2022 Mar; (): .
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2022piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development., Dev Cell 2022 Jan; 57(2): 180-196.e7.
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2021Live single-cell transcriptional dynamics via RNA labelling during the phosphate response in plants., Nat Plants 2021 08; 7(8): 1050-1064.
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2021Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting., Nat Commun 2021 07; 12(1): 4503.
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2021Spatial transcriptomics for respiratory research and medicine., Eur Respir J 2021 Apr; (): .
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2021Germline inherited small RNAs facilitate the clearance of untranslated maternal mRNAs in C. elegans embryos., Nat Commun 2021 03; 12(1): 1441.
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2021A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport., Nat Commun 2021 Mar; 12(1): 1352.
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2021Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophages., EMBO J 2021 Jan; 40(1): e105247.
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2020Functional compensation precedes recovery of tissue mass following acute liver injury., Nat Commun 2020 11; 11(1): 5785.
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