I’m a trained biophysicist and develop integrated approaches combining fluorescence imaging, computerized image analysis, and mathematical modeling. Equipped with these skills, I want to contribute to a better quantitative understanding of biological processes. My current focus is on gene expression, however, this integrated approach can be readily applied to other biological questions where imaging and modeling form an integral part to obtain a deeper quantitative understanding.
Fluorescence microscopy is a defining technology in cellular biology but the diffraction of light limits the resolution of standard microscopes to ~200 nm, thus preventing detailed analyses of molecular structures. We are actively interested […]
Nuclear architecture and function
The one-dimensional sequence of the genome is carried by long polymers (chromosomes), which fold in the three dimensional volume of the nucleus. How this folding occurs and what it implies for genome function remains […]
FISH-quant: automatically counting transcripts in RNA-FISH images
A free Matlab-based toolbox to detect and count individual mRNA transcripts in single cells by automatic analysis of 3D RNA-FISH images. Software is available freely together with extensive instructions at : https://code.google.com/p/fish-quant/. The […]
- Graz University of Technology, Austria and National Institutes of Health (NIH), Bethesda; 2005 – 2008
- Thesis: Quantitative analysis of the dynamic properties of chromatin associated proteins by FRAP experiments
- Advisors: Dr. James G. McNally, Dr. Zlatko Trajanoski
- Computational Physics, Universität Graz, Austria, 1999 – 2005
- Thesis: Numerical Simulations of FRAP Experiments
- Advisors: Dr. Max Lippitsch, Dr. Zlatko Trajanoski
2021Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting., Nat Commun 2021 07; 12(1): 4503.
2021Spatial transcriptomics for respiratory research and medicine., Eur Respir J 2021 Apr; (): .
2021Germline inherited small RNAs facilitate the clearance of untranslated maternal mRNAs in C. elegans embryos, Nat Commun . 2021 Mar 4;12(1):1441..
2021A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport., Nat Commun 2021 Mar; 12(1): 1352.
2021Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophages., EMBO J 2021 Jan; 40(1): e105247.
2021Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH, bioRxiv.
2020Functional compensation precedes recovery of tissue mass following acute liver injury., Nat Commun 2020 11; 11(1): 5785.
2020A Dual Protein-mRNA Localization Screen Reveals Compartmentalized Translation and Widespread Co-translational RNA Targeting., Dev Cell 2020 Sep; 54(6): 773-791.e5.
2020mRNA localization is linked to translation regulation in the Caenorhabditis elegans germ lineage., Development 2020 Jun; (): .
2020Remodeling of the Core Leads HIV-1 Preintegration Complex into the Nucleus of Human Lymphocytes., J Virol 2020 05; 94(11): .
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