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CV

Education :

2015  : Tufts University Medford, MA : B.S. in Biology, Magna Cum Laude
Minors in Leadership Studies & Theatre

 

Research Experience :

2021- Present : Pasteur lnstitute Paris, FR
PPU Doctoral Candidate, Translational lmmunology
Impact of variable immunometabolic  pathways on immune responses in health and infection

2020 – 2021 : Gritstone Oncology Cambridge, MA
Associate Scientist, NGS and Molecular Biology
2018-2020 : Gritstone Oncology Cambridge, MA
Senior Research Associate,
NGS and Molecular Biology
Translational Immune Sequencing lead for Phase I cancer vaccine trial & academic collaborations

Investigated  our neoantigen  vaccine’s mechanism  of action by correlating T celisequencing of patients’ blood and tumor in cross-functional immune monitoring

  • Optimized single-cell & tissue sequencing for diverse clinical samples
  • Coded pipeline for multi-modal data integration and curation to enable in-depth analysis (Python)
  • Benchmarked deep learning tools to analyze T cell phenotype and TCR evolution (R, Python)
  • Training new colleagues & interns on lab and computational analysis protocols

Performed similar TCR analysis for academic collaborations with Columbia, NCI, and University of Chicago

2017-2018 : AstraZeneca Waltham,MA
Scientist, Translational Genomics
Lead investigator of T-cell receptor sequencing for improving Phase II+ immuno-oncology treatment

  • Optimized new NGS and RNAseq assays in vitro & in silico and applied to multiple Phase II/ Platform studies
  • Interrogated translational data to inform patient selection and combination strategies (R & Bash)
  • Applied learnings across other IO biomarker programs (B-cell receptor sequencing)

2015  – 2017 : AstraZeneca Waltham,MA
Graduate Scientist
Rotational Graduate Scientist program

  • Rotation A: Translational lmmuno-oncology — began TCRseq project continued as Translational Scientist
  • Rotation B: Oncology Translational Science Next Generation Sequencing — supported Phase l -Ill clinical projects by executing NGS pipeline from sample acquisition to sequencing data analysis. Drove validation and implementation of novel sample fingerprinting panel into our clinical sample pipeline
  • Rotation C: Oncology Bioscience ln Vivo– characterized resistance mechanisms from small-molecule Phase lIb clinical data via mutant cell line generation and in vitro assays. Conclusions informed Phase Ill patient selection and resulted in resistance reformulation

2014 : Tufts University Medford, MA
Research Assistant with Dr. David Kaplan, Biomedical Engineering
Developed a human lung disease model on a silk-collagen scaffold

  • Optimized silk processing. collagen coating. and co-culturing of primary lung cells, successfully seeding them in a 3-D tubular silk scaffold
  • Defended resulting mini-thesis to faculty committee, awarded highest honors

2014 : Tufts University Medford, MA
Research Assistant with Dr. Catherine Freudenreich, Molecular  Biology
Investigated  the effect of DNA post-replication  repair  protein deletions on Huntington’s CG expansion

2014 : Pfizer lnc. Cambridge, MA
Bioconjugation, Biophysics, and Biochemistry lntern

 

Skills & Techniques :

WetLab:
NGS & RNAseq (bulk & single-cell)
FACs
qPCR
Clinical nucleic acid extraction
ELISA & Western Blots
Primary human cell culture
Mutant cellline generation
Immunostaining

Software:
R
Python
Seurat
10x Genomics suite
Broad  Institute’s IGV
Graphpad Prism
Photoshop

Instruments:
Illumina  Sequencers
Hamilton STAR
Beckman Coulter Liquid  Handlers
Kingfisher Flex
Covaris M220
Agilent TapeStation
ThermoFisher QuantStudio

 

Awards & Recognitions

AstraZeneca R&D Innovation Award (2016)- nominated by manager, awarded by committee for research excellence

Honos Civicus Society (2015)- recognized by faculty committee for service throughout Tufts education Dean’s List (2011- 2015)

Girl Scout Gold  Award (2011) – planned, organized, and  trained other coaches in teaching tennis to teens with special needs during a six-week clinic

 

Posters & Presentations

Maloney. E: “What T cells can tell us about Lung Cancer  Immunotherapy” Precision Lung Cancer  Summit, 2020.

Maloney. E: “TCR Biomarkers in Cancer Immunotherapy Development” NextGeneration DX Summit, 2019.

Maloney,  E: McGrath,  L; Stetson, D; Lubinski, TJ; Kirchner, R; Dougherty, B; Barrett, JC. Using liquid  biopsies ta monitor the tumor immune microenvironment in cancer patients with solid  malignancies. AstraZeneca-Oxford Symposium, 2018.

Maloney. E: McGrath,  L; Stetson, D; Lubinski, TJ; Kirchner, R; Dougherty, B; Barrett, JC. Cap turing T cell receptor clones from  circulating free DNA in cancer patients with  solid malignancies. AACRAnnual  Meeting, 2018.

Maloney   E: McGrath,  L; Lubinski, TJ; Sail, S; Tron, A; Prickett, L; Stetson, D; Dougherty, B; Barrett, )C. Optimizing T cell receptor repertoire characterization through Next Generation Sequencing. Festival  of Genomics, 2017.

Maloney. E.; Nuttall, B.; Stetson, D.; Ahmed,  A.; Lubinski, T.; Sa if, S.; Bushoy, A.; Saveliev, V.; johnson,).; Dougherty, B.; Barrett, C. Clinical Sample DNA “Fingerprinting”. Graduate Poster Presentation Session, 2017.

Johnson, M., [et al, including Maloney, E.] First  Results of Phase  I/ll Studies Evaluating Viral Vector-based Heterologous Prime/Boost Immunotherapy Against Predicted HLA Class I  Neoantigens Demonstrate COB T-Cell Responses in Patients with Advanced Cancers. ESMO 10,2019.

Busby J., [et al, including Maloney, E.] Identification and Validation of Shared Neoantigens for Cancer  Immunotherapy. SITC, 2019.

Jalloh  A., [et al, including Maloney, E.] “Efficient Identification of T Cell Receptors against Shared Neoantigens” PEGS Europe, 2019.

Palmer C.D., [et al. including Maloney, E.]”Identification of pre-existing neoantigen-specific T cells in patients receiving checkpoint inhibitor therapy using a deep learning antigen prediction model” AACR An nuai Meeting, 2019.

McGrath  L., [et al. including Maloney, E.] “Intratumoral T cell receptor b repertoire as a biormarker in head and  neck squamous cell carcinoma” AACR Conference on Tumor Irnmunology & Irnmunotherapy, 2018.

Frigault. MM, [et al. including Maloney, E.] “Response to Savolitinib in papillary renal  ceil carcinoma patient harboring a novel MET activating mutation” ESMO, 2016.

Barry, E., [et al. including Maloney, E.] “Targeting MET Exon 14 mutations with the selective small  molecule inhibitor Savolitinib” AACR, 2016.

 

Leadership & Service :

2020- Present : Scientists in Solidarity Boston, MA
Collaborations Volunteer

2020- 2021 : Science Club for Girls Cambridge, MA
Volunteer

2016-2019 : Big Brothers Big Sisters Waltham, MA
Mentor

2016-2018 : AstraZeneca Network  of Women Waltham, MA
Collaborations Chair, Board Member

2016-2017 : AstraZeneca Early Talent Waltham, MA
Philanthropy Chair

2015 : Museum of Science Boston, MA
Lab Interpretation lntern

2012-2015 : Girl Scouts of the Leonard Carmichael Society, Tufts University Medford, MA
Co-Founder, President, Troop Leader