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© Research
Member: Permanent Researcher

Elisabeth Labruyère

• Biological Image Analysis

Laboratory: Biological Image Analysis
Scientific Fields
Diseases
Organisms
Applications
Technique

About

My interest is to study the mechanobiology of the intestinal invasion by the pathogenic amoeba Entamoeba histolytica, by analyzing the role of amoebic and environmental factors (biological and mechanical) on its migration through the colonic tissue.

Projects

Project
Ongoing
5 Members

Call Emulate 2020 – Mucibiome – Impact of the colon mucus layer colonized by microbiota on the colonic epithelium mechanics under strech and on the pathogenesis of Entamoeba histolytica

Elisabeth Labruyère (PI)

In the human colon, mucus protects the underlying epithelium from pathogens. During infection, pathogens and resident microbiota compete for nutritional metabolites and therefore changes may alter the equilibrium in the colon ecosystem contributing to […]
Project
Ongoing
7 Members

PTR 232-2019. Mechabiome. Computational imaging of the spatiotemporal distribution of forces in gut tissue: a study of the cross talk between cell mechanics, microbiome and infectious processes

Elisabeth Labruyère (PI)

Mechanical forces trigger many cellular functions and change the geometry and physical properties of a tissue. Very few studies look at the biomechanisms of invasion of microbes at tissue level. – In this project […]
Project
Ongoing
6 Members

Impact of tissue components on cell migration: adhesion strength, cell morpho-dynamics and intracellular biophysics parameters.

Elisabeth Labruyère (PI)

We aim to analyze the impact of substrates on Entamoeba histolytica mode of migration during colonic mucosa invasion using live imaging and quantitative image analysis. E. histolytica, the etiological agent of amoebiasis, is a […]
Project
Ongoing
6 Members

Impact of gut mechanical forces and 3D architecture on the intestine homeostasis during pathogen interaction and in cancer disease

Nathalie Sauvonnet (PI)

The intestine, and in particular the colon, comprising a mucus blanket, an epithelial monolayer and the lamina propria rich in immune cells, is constantly subjected to shear stress (flow) and peristaltic motion (stretching), both […]
Project
Ongoing
16 Members

Organ-on-Chip Center

Samy Gobaa (PI)

What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]

Publications

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