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  • tool
  • patent
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  • Assistant Professor
  • Associate Professor
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  • Clinician Researcher
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  • Graduate Student
  • Honorary Professor
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  • Permanent Researcher
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  • PhD Student
  • Physician
  • Post-doc
  • Prize
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  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
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  • Head of Facility
  • Head of Operations
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  • Honorary President of the Departement
  • Labex Coordinator
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© Research
Scientific Fields
Diseases
Organisms
Applications
Technique

Projects

Project
Ongoing
8 Members

Projet de Recherche Clinique : Impact des mutations du gène APC (Adenomatous polyposis coli) dans les réponses immunes anti-tumorales

Andres Alcover (PI)

La polypose adénomateuse familiale est une maladie caractérisée par l’apparition dans l’intestin de nombreux polypes susceptibles d‘évoluer en cancer en l’absence de prise en charge. Il s’agit d’une maladie génétique rare, le plus souvent […]
Project
Ongoing
18 Members

CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie

Hélène Laude (PI)

Rationnel La polypose adénomateuse familiale se manifeste par l’apparition dans l’intestin de nombreuses excroissances dénommées polypes adénomateux et susceptibles d‘évoluer en cancers en l’absence de prise en charge. Il s’agit d’une maladie génétique, le […]
Project
Ongoing
4 Members

How the dynamics of signaling complexes at the immunological synapse controls T cell activation

Vincenzo Di Bartolo (PI)

 Signals generated by the engagement of the T cell antigen receptor are decoded and integrated by molecular complexes that form at the immunological synapse upon T cell receptor engagement. Assembly of these complexes, as […]
Project
Ongoing
11 Members

Cytoskeleton, immunological synapse and T cell activation: role of Ezrin and Adenomatous polyposis coli

Andres Alcover (PI)

Antigen recognition by the T cell receptor triggers extensive rearrangements of both the actin and microtubule cytoskeleton. Cytoskeleton changes condition in turn morphological changes and molecular reorganization at the immunological synapse (Figure). We have […]