Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
Scientific Fields
Diseases
Organisms
Applications
Technique
Application Deadline
31
Dec 2019
2019-12-31 8:00:00 2019-12-31 18:00:00 Europe/Paris TRamWAy Postdoctoral fellowship Description   The TramWay project aims at designing an entirely automated procedure to study the random walks (RWs) of biomolecules in living cells. At the nanoscale, the dynamics of individual biomolecules is inherently random, […] "25-28 rue du Dr. Roux, 75015, Paris" Jean-Baptiste Masson jean-baptiste.masson@pasteur.fr

Description

 

The TramWay project aims at designing an entirely automated procedure to study the random walks (RWs) of biomolecules in living cells. At the nanoscale, the dynamics of individual biomolecules is inherently random, governed by thermal noise and stochastic molecular interactions. By giving access to the full distribution of molecular properties, rather than simply their average value, the great advantage of single molecule measurements is thus their ability to identify static and dynamic heterogeneities, and rare behaviours. Local heterogeneities, numerous specific and non-specific interactions, and unknown number of molecular partners in the cellular environment lead to extremely unusual properties of biological RWs, making the inference of their nature a challenging statistical and computational problem.

 

More information on the application of TRamWAy to synapses is available at the following address: https://research.pasteur.fr/en/project/mapping-receptor-dynamics-in-synapses/

 

We are proposing a 2-year postdoctoral fellowship financed by the “TRamWAy” ANR project for a motivated applicant. She/he is expected to contribute to our efforts in designing amortized inference approaches for RWs described by predictive models and in developing an unsupervised structured inference framework to probe random walks that cannot be described by a canonical model, e.g. such as a fractional Brownian motion or a hidden Markov model. We are looking for either a physicist with a strong statistical physics background or a computer scientist with experience in complex, large-scale variational inferences.

 

The successful candidate will have privileged access to multiple GPU clusters in the Pasteur institute as well as a CPU cluster. Furthermore, she/he will join a full team working on the project composed of Christian L. Vestergaard, who developed a non-tracking algorithm using belief propagation and unseen graph summation to infer biomolecule dynamics at high density, Francois Laurent, who designed the TRamWAy software platform and is currently developing stochastic gradient approaches to infer time varying 2D/3D maps of biomolecule dynamics at the full cell scale, and Alexander Serov, who after designing Bayesian evidence tests for Ito-Stratonovitch dilemma is developing amortized approaches to detect out-of-equilibrium dynamics from recorded RWs.

 

Required Skills

For a physicist:  statistical physics and random walk theory

For a computer scientist: Bayesian Inference, structured and variational inferences

Scripting language experience: Bash, Python

 

Nice to have Skills

Tensorflow/Keras/pytorch

 

Duration

2 years

 

Localization

Institut Pasteur (Paris)

 

Contact Information

Interested candidates should contact Jean-Baptiste Masson (jbmasson@pasteur.fr) with their CV, a brief motivation letter and 2 letters of recommendation.