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© Research
Event

“The systems genetics of aging : evolutionary, functional and pharmacological perspectives” by Patrick C. PHILLIPS – Genomes and Genetics departemental seminar

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
05
Apr 2018
Time
11:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: MONOD Room: Amphi JACQUES MONOD
Location
2018-04-05 11:00:00 2018-04-05 12:30:00 Europe/Paris “The systems genetics of aging : evolutionary, functional and pharmacological perspectives” by Patrick C. PHILLIPS – Genomes and Genetics departemental seminar Patrick C. Phillips, Ph.D. Acting Executive Director | Professor of Biology Phil and Penny Knight Campus for Accelerating Scientific Impact https://www.uoregon.edu/accelerate https://www.uoregon.edu/~pphi   Abstract: Aging is the inevitable fate of all organisms yet is […] Institut Pasteur, Rue du Docteur Roux, Paris, France Louis Lambrechts louis.lambrechts@pasteur.fr

About

Patrick C. Phillips, Ph.D.
Acting Executive Director | Professor of Biology
Phil and Penny Knight Campus for Accelerating Scientific Impact
https://www.uoregon.edu/accelerate
https://www.uoregon.edu/~pphi
 
Abstract:
Aging is the inevitable fate of all organisms yet is highly heterogeneous in nature. It is thought that genetic differences in resistance to environmental stress is one source of individual differences in life a nd healthspan. We have examined the complex genetic basis of natural variation in stress resistance in nematodes using experimental evolution and high throughput functional genomics. Additionally, we have been systematically investigating the influence of genetic background on the response to chemical interventions aimed at extending lifespan. Overall, natural variation for longevity and stress resistance is complex and appears to involve a large fraction of the genome. The large degree of experimental and genetic heterogeneity of these effects suggests that even more precise approaches are needed in our studies. To that end, we are developing microfluidic and single-cell approaches to precisely study the phenotypic and genomic responses to stress and their consequences for healthy aging.

Location

Building: MONOD
Room: Amphi JACQUES MONOD
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France