Présentation
Patrick C. Phillips, Ph.D.
Acting Executive Director | Professor of Biology
Phil and Penny Knight Campus for Accelerating Scientific Impact
Abstract:
Aging is the inevitable fate of all organisms yet is highly heterogeneous in nature. It is thought that genetic differences in resistance to environmental stress is one source of individual differences in life a nd healthspan. We have examined the complex genetic basis of natural variation in stress resistance in nematodes using experimental evolution and high throughput functional genomics. Additionally, we have been systematically investigating the influence of genetic background on the response to chemical interventions aimed at extending lifespan. Overall, natural variation for longevity and stress resistance is complex and appears to involve a large fraction of the genome. The large degree of experimental and genetic heterogeneity of these effects suggests that even more precise approaches are needed in our studies. To that end, we are developing microfluidic and single-cell approaches to precisely study the phenotypic and genomic responses to stress and their consequences for healthy aging.
Localisation
Bâtiment: MONOD
Adresse: Institut Pasteur, Rue du Docteur Roux, Paris, France
(function($) {
/*
* render_map
*
* This function will render a Google Map onto the selected jQuery element
*
* @type function
* @date 8/11/2013
* @since 4.3.0
*
* @param $el (jQuery element)
* @return n/a
*/
function render_map( $el ) {
var MY_MAPTYPE_ID = 'custom_style';
var featureOpts = [{"stylers":[{"hue":"#0088ff"}]}];
var styledMapOptions = {
name: 'Custom Style'
};
var customMapType = new google.maps.StyledMapType(featureOpts, styledMapOptions);
// var
var $markers = $el.find('.marker');
// vars
var args = {
zoom : 16,
scrollwheel : false,
center : new google.maps.LatLng(0, 0),
mapTypeId : google.maps.MapTypeId.ROADMAP,
mapTypeId : MY_MAPTYPE_ID
};
// create map
var map = new google.maps.Map( $el[0], args);
map.mapTypes.set(MY_MAPTYPE_ID, customMapType);
// add a markers reference
map.markers = [];
// add markers
$markers.each(function(){
add_marker( $(this), map );
});
// center map
center_map( map );
}
/*
* add_marker
*
* This function will add a marker to the selected Google Map
*
* @type function
* @date 8/11/2013
* @since 4.3.0
*
* @param $marker (jQuery element)
* @param map (Google Map object)
* @return n/a
*/
function add_marker( $marker, map ) {
// var
var latlng = new google.maps.LatLng( $marker.attr('data-lat'), $marker.attr('data-lng') );
//var image = 'https://research.pasteur.fr/wp-content/themes/biologyx2/images/logomap.png';
var myIcon = new google.maps.MarkerImage('https://research.pasteur.fr/wp-content/themes/biologyx2/images/map-pin.png', null, null, null, new google.maps.Size(32,32));
// create marker
var marker = new google.maps.Marker({
position : latlng,
map : map,
icon : myIcon
});
// add to array
map.markers.push( marker );
// if marker contains HTML, add it to an infoWindow
if( $marker.html() )
{
// create info window
var infowindow = new google.maps.InfoWindow({
content : $marker.html()
});
// show info window when marker is clicked
google.maps.event.addListener(marker, 'click', function() {
infowindow.open( map, marker );
});
}
}
/*
* center_map
*
* This function will center the map, showing all markers attached to this map
*
* @type function
* @date 8/11/2013
* @since 4.3.0
*
* @param map (Google Map object)
* @return n/a
*/
function center_map( map ) {
// vars
var bounds = new google.maps.LatLngBounds();
// loop through all markers and create bounds
$.each( map.markers, function( i, marker ){
var latlng = new google.maps.LatLng( marker.position.lat(), marker.position.lng() );
bounds.extend( latlng );
});
// only 1 marker?
if( map.markers.length == 1 )
{
// set center of map
map.setCenter( bounds.getCenter() );
map.setZoom( 15 );
}
else
{
// fit to bounds
map.fitBounds( bounds );
}
}
/*
* document ready
*
* This function will render each map when the document is ready (page has loaded)
*
* @type function
* @date 8/11/2013
* @since 5.0.0
*
* @param n/a
* @return n/a
*/
$(document).ready(function(){
$('.acf-map').each(function(){
render_map( $(this) );
});
});
})(jQuery);
