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© Lydie Couturier , Institut Pasteur
Organes sensoriels en développement chez la drosophile
Event

SEMINAR “ESCRT-positive exovesicles in animal development” by Maximilian Fürthauer

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
10
Mar 2017
Time
12:00:00
25 Rue du Docteur Roux, Paris, France
Address
Building: (#66)
Location
2017-03-10 12:00:00 2017-03-10 13:15:00 Europe/Paris SEMINAR “ESCRT-positive exovesicles in animal development” by Maximilian Fürthauer Department of Developmental and Stem Cell Biology 2017 Seminar Series Friday 10th March — at 12.00 pm @ Amphi Jacques Monod (Bât.66) SEMINAR ” ESCRT-positive exovesicles in animal development “ Invited Speaker ⇒ Maximilian […] 25 Rue du Docteur Roux, Paris, France Laure Bally-Cuif laure.bally-cuif@pasteur.fr

About

Department of Developmental and Stem Cell Biology

2017 Seminar Series

Friday 10th March — at 12.00 pm @ Amphi Jacques Monod (Bât.66)

SEMINAR ” ESCRT-positive exovesicles in animal development “

Invited Speaker Maximilian Fürthauer

IBV – Institut de Biologie de Valrose
CNRS UMR7277, Inserm U1091, UNS – France

Abstract : The Endosomal Sorting Complex Required for Transport (ESCRT) is an evolutionarily conserved membrane remodeling machinery that is best known for its essential function in the intra-endosomal sorting of ubiquitinated growth factor receptors towards the intra-lumenal vesicles of multivesicular endosomes. In addition to this role in endosomal biogenesis, a number of studies have led to the identification of additional roles of the ESCRT machinery in processes ranging from cytokinetic abscission to membrane repair and exovesicle release. While the ESCRT complex has been studied extensively with respect to its function in the endocytic regulation of cell signaling, much less is known with respect to the physiological relevance of these more recently discovered ESCRT activities. Our lab uses Drosophila and Zebrafish to study ESCRT function in animal development. In the course of this work, we have found that ESCRT proteins are detected on extracellular vesicles that are present in the lumenal space of epithelial organs in both fish and flies. The data that I will present suggest that ESCRT-positive exovesicles may play an important role in the extracellular transport of developmental signaling molecules.

Hosted by Laure Bally-Cuif

Location

Building: (#66)
Address: 25 Rue du Docteur Roux, Paris, France