Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Research
Scientific Fields
Diseases
Organisms
Applications
Technique
Date
12
May 2022
Time
15:00:00
Address
Building: 27 Room: François Jacob Auditorium
Location
2022-05-12 15:00:00 2022-05-12 17:00:00 Europe/Paris Microphysiological models of tissue barriers: new tools for infection biology Mucosal tissue barriers, as the site of ‘first contact’ play an important role in the pathology of several infectious diseases, including tuberculosis (TB), COVID-19 and urinary tract infections. The role of tissue microenvironment in […] Samy Gobaa samy.gobaa@pasteur.fr

About

Mucosal tissue barriers, as the site of ‘first contact’ play an important role in the pathology of several infectious diseases, including tuberculosis (TB), COVID-19 and urinary tract infections. The role of tissue microenvironment in infection outcomes can be difficult to dissect in a mechanistic manner in situ in animal models. For example, the minimum infectious dose in TB can be as low as one, which makes the early stages of infection difficult to study. Yet heterogenous outcomes in the early stages of infection may explain why the proportion of exposed individuals who develop clinical tuberculosis is low. In contrast, severe COVID-19 leads to profound microvascular damage in patients, but the direct role of the vasculature in COVID-19 is difficult to study in vitro, because endothelial cell monoculture models are resistant to direct infection with SARS-CoV-2 and do not develop inflammatory responses. Similarly, the dynamics of invasion of the bladder epithelium by uropathogenic E. coli (UPEC) are difficult to access in vivo. In my talk, I will describe our efforts to develop microphysiological models for infectious diseases, highlight the common challenges as well as tissue and pathogen-specific differences, and showcase the ability of these systems to enable new experiments that would not be possible in vivo.