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Microbiology Dpt – Thesis defense by Silke Schmidt – “Functional analyses of the Legionella longbeachae capsule to understand its role in host immune sensing and environmental persistence”

Department of Immunology seminar: Singer Kanadurga Friday 13 October 12.00pm BY TEAMS

© Xavier Montagutelli, Institut Pasteur

Event

Genomes and Genetics department seminar: Clare Smith (Duke University, Durham, USA); Thursday 18 April @11:00am ; Auditorium François Jacob

Team: Mouse Genetics

Department of: Genomes and Genetics

Member: Xavier Montagutelli

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

18

Apr 2024

Time

11:00:00

Address

Room: Auditorium F. Jacob

Location

2024-04-18 11:00:00 2024-04-18 12:00:00 Europe/Paris Genomes and Genetics department seminar: Clare Smith (Duke University, Durham, USA); Thursday 18 April @11:00am ; Auditorium François Jacob Thursday 18 April @ 11:00 am Auditorium F. Jacob (CFJ building) Clare M. SMITH Department of Molecular Genetics and Microbiology, Duke University, Durham – USA Host vs Pathogen: discovering genetic drivers of diverse tuberculosis outcomes. Abstract: Genetic diversity […] Xavier Montagutelli xavier.montagutelli@pasteur.fr

Speakers

(Department of Molecular Genetics and Microbiology, Duke University Durham - USA)

About

Thursday 18 April @ 11:00 am

Auditorium F. Jacob (CFJ building)

Clare M. SMITH

Department of Molecular Genetics and Microbiology, Duke University, Durham – USA

Host vs Pathogen: discovering genetic drivers of diverse tuberculosis outcomes.

Abstract:

Genetic diversity is a key factor underlying heterogenous disease states of tuberculosis. However, current standard mouse models fail to incorporate both genetic and phenotypic diversity. We approach this problem by leveraging new mammalian and bacterial genetic resources to study each of these variables in isolation and in combination. Host diversity is modeled using the new mammalian genetics resource known as the Collaborative Cross (CC). The CC is a genetically diverse but reproducible panel of mice, which show diverse immunity and infection outcomes. Bacterial variation is concurrently incorporated using new genetic reporters or libraries of M. tuberculosis mutants (TnSeq). Using this highly tractable system, our research program focuses on defining the mechanisms by which genetic variation in the host and pathogen impact interventions and outcomes to infectious diseases in model systems and human patients. By combining both host and bacterial genetics approaches, we are defining the host pathways that mediate protection, and the bacterial tactics used to exploit and evade them.

Published on: 09 Oct 2023 • Modified on: 05 Apr 2024

(function($) { /* * render_map * * This function will render a Google Map onto the selected jQuery element * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param $el (jQuery element) * @return n/a */ function render_map( $el ) { var MY_MAPTYPE_ID = 'custom_style'; var featureOpts = [{"stylers":[{"hue":"#0088ff"}]}]; var styledMapOptions = { name: 'Custom Style' }; var customMapType = new google.maps.StyledMapType(featureOpts, styledMapOptions); // var var $markers = $el.find('.marker'); // vars var args = { zoom : 16, scrollwheel : false, center : new google.maps.LatLng(0, 0), mapTypeId : google.maps.MapTypeId.ROADMAP, mapTypeId : MY_MAPTYPE_ID }; // create map var map = new google.maps.Map( $el[0], args); map.mapTypes.set(MY_MAPTYPE_ID, customMapType); // add a markers reference map.markers = []; // add markers $markers.each(function(){ add_marker( $(this), map ); }); // center map center_map( map ); } /* * add_marker * * This function will add a marker to the selected Google Map * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param $marker (jQuery element) * @param map (Google Map object) * @return n/a */ function add_marker( $marker, map ) { // var var latlng = new google.maps.LatLng( $marker.attr('data-lat'), $marker.attr('data-lng') ); //var image = 'https://research.pasteur.fr/wp-content/themes/biologyx2/images/logomap.png'; var myIcon = new google.maps.MarkerImage('https://research.pasteur.fr/wp-content/themes/biologyx2/images/map-pin.png', null, null, null, new google.maps.Size(32,32)); // create marker var marker = new google.maps.Marker({ position : latlng, map : map, icon : myIcon }); // add to array map.markers.push( marker ); // if marker contains HTML, add it to an infoWindow if( $marker.html() ) { // create info window var infowindow = new google.maps.InfoWindow({ content : $marker.html() }); // show info window when marker is clicked google.maps.event.addListener(marker, 'click', function() { infowindow.open( map, marker ); }); } } /* * center_map * * This function will center the map, showing all markers attached to this map * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param map (Google Map object) * @return n/a */ function center_map( map ) { // vars var bounds = new google.maps.LatLngBounds(); // loop through all markers and create bounds $.each( map.markers, function( i, marker ){ var latlng = new google.maps.LatLng( marker.position.lat(), marker.position.lng() ); bounds.extend( latlng ); }); // only 1 marker? if( map.markers.length == 1 ) { // set center of map map.setCenter( bounds.getCenter() ); map.setZoom( 15 ); } else { // fit to bounds map.fitBounds( bounds ); } } /* * document ready * * This function will render each map when the document is ready (page has loaded) * * @type function * @date 8/11/2013 * @since 5.0.0 * * @param n/a * @return n/a */ $(document).ready(function(){ $('.acf-map').each(function(){ render_map( $(this) ); }); }); })(jQuery);