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Club viro délocalisé

Immunoprofiling human T cell responses in health and disease

© K. Melican.

Human microvessel (red) colonized by N. meningitidis (green).

Event

“Host cell colonization by Mycobacterium tuberculosis: recent insights on the early onset” – Priscille Brodin

Team: Pathogenesis of vascular infections

Team: Dynamics of Host-Pathogen Interactions

Department of: Cell Biology & Infection

Member: Guillaume Dumenil

Member: Jost Enninga

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

13

Nov 2017

Time

12:00:00

28 Rue du Docteur Roux, Paris, France

Address

Building: François Jacob

Location

2017-11-13 12:00:00 2017-11-13 18:00:00 Europe/Paris “Host cell colonization by Mycobacterium tuberculosis: recent insights on the early onset” – Priscille Brodin Séminaire “Host cell colonization by Mycobacterium tuberculosis: recent insights on the early onset” présenté par Priscille Brodin (Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 – UMR 8204 – CIIL – […] 28 Rue du Docteur Roux, Paris, France Guillaume Dumenil guillaume.dumenil@pasteur.fr

About

Séminaire

“Host cell colonization by Mycobacterium tuberculosis:

recent insights on the early onset”

présenté par Priscille Brodin

(Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille,

U1019 – UMR 8204 – CIIL – Centre d’Infection et d’Immunité de Lille)

Lundi 13 novembre à 12h00

Auditorium F. Jacob

Invitée par Guillaume Duménil & Jost Enninga

contacts: Anne Kongchanh (anne.kongchanh@pasteur.fr) &

Laurence Langlais ( laurence.langlais@pasteur.fr)

Abstract :

The highly successful pathogen Mycobacterium tuberculosis colonizes and replicates within different lung cell types and leads to the formation of a granuloma, the ultimate hallmark of most tuberculosis cases in adults. The interactions of pathogenic M. tuberculosis with the various cell types at early stages of bacillus colonization are still poorly understood, and the detailed molecular and cellular mechanisms are still unclear. Using a systems biology approach, we identified novel key host signaling pathways, which will be presented here. First, I will demonstrate how Arf1-dependent rearrangements of the actin cytoskeleton influence and restrict mycobacterial uptake in human epithelial cells. Second, I will show how M. tuberculosis counteracts the first line of acid defense in macrophages by co-opting cytokine-inducible SH2-containing protein (CISH) signaling.

Location

Building: François Jacob
Address: 28 Rue du Docteur Roux, Paris, France

Published on: 07 Nov 2017

(function($) { /* * render_map * * This function will render a Google Map onto the selected jQuery element * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param $el (jQuery element) * @return n/a */ function render_map( $el ) { var MY_MAPTYPE_ID = 'custom_style'; var featureOpts = [{"stylers":[{"hue":"#0088ff"}]}]; var styledMapOptions = { name: 'Custom Style' }; var customMapType = new google.maps.StyledMapType(featureOpts, styledMapOptions); // var var $markers = $el.find('.marker'); // vars var args = { zoom : 16, scrollwheel : false, center : new google.maps.LatLng(0, 0), mapTypeId : google.maps.MapTypeId.ROADMAP, mapTypeId : MY_MAPTYPE_ID }; // create map var map = new google.maps.Map( $el[0], args); map.mapTypes.set(MY_MAPTYPE_ID, customMapType); // add a markers reference map.markers = []; // add markers $markers.each(function(){ add_marker( $(this), map ); }); // center map center_map( map ); } /* * add_marker * * This function will add a marker to the selected Google Map * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param $marker (jQuery element) * @param map (Google Map object) * @return n/a */ function add_marker( $marker, map ) { // var var latlng = new google.maps.LatLng( $marker.attr('data-lat'), $marker.attr('data-lng') ); //var image = 'https://research.pasteur.fr/wp-content/themes/biologyx2/images/logomap.png'; var myIcon = new google.maps.MarkerImage('https://research.pasteur.fr/wp-content/themes/biologyx2/images/map-pin.png', null, null, null, new google.maps.Size(32,32)); // create marker var marker = new google.maps.Marker({ position : latlng, map : map, icon : myIcon }); // add to array map.markers.push( marker ); // if marker contains HTML, add it to an infoWindow if( $marker.html() ) { // create info window var infowindow = new google.maps.InfoWindow({ content : $marker.html() }); // show info window when marker is clicked google.maps.event.addListener(marker, 'click', function() { infowindow.open( map, marker ); }); } } /* * center_map * * This function will center the map, showing all markers attached to this map * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param map (Google Map object) * @return n/a */ function center_map( map ) { // vars var bounds = new google.maps.LatLngBounds(); // loop through all markers and create bounds $.each( map.markers, function( i, marker ){ var latlng = new google.maps.LatLng( marker.position.lat(), marker.position.lng() ); bounds.extend( latlng ); }); // only 1 marker? if( map.markers.length == 1 ) { // set center of map map.setCenter( bounds.getCenter() ); map.setZoom( 15 ); } else { // fit to bounds map.fitBounds( bounds ); } } /* * document ready * * This function will render each map when the document is ready (page has loaded) * * @type function * @date 8/11/2013 * @since 5.0.0 * * @param n/a * @return n/a */ $(document).ready(function(){ $('.acf-map').each(function(){ render_map( $(this) ); }); }); })(jQuery);