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© Romain Levayer, Institut Pasteur
Epithelial layer of the Drosophila pupal thorax (notum). White : cell contour (E-cadherin), pseudocolour : Dpp sensor.
Event

Developmental and Stem Cell Biology Department seminar by Doctor Jochen Rink, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
16
Nov 2018
Time
11:00:00
Institut Pasteur, 25 Rue du Docteur Roux, 75015 Paris, France
Address
Building: J.Monod (#66) Room: Monod 7th floor, rooms 2 & 3 a+b
Location
2018-11-16 11:00:00 2018-11-16 12:00:00 Europe/Paris Developmental and Stem Cell Biology Department seminar by Doctor Jochen Rink, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany “Why some worms regenerate while others cannot – molecular and evolutionary mechanisms in planarian regeneration” Invited Speaker: Doctor Jochen Rink Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany   Abstract: Some […] Institut Pasteur, 25 Rue du Docteur Roux, 75015 Paris, France Romain Levayer romain.levayer@pasteur.fr

About

“Why some worms regenerate while others cannot – molecular and evolutionary mechanisms in planarian regeneration”

Invited Speaker: Doctor Jochen Rink

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

 

Abstract: Some animals have the ability to regenerate body parts lost to injury, while already closely related species are often unable to regenerate. Why regeneration should remain an exception rather then the rule represents a fascinating question in the face of “survival of the fittest”. My lab studies the ability of planarian flatworms to regenerate complete animals from random tissue fragments as model system for regeneration. In addition, we are pioneering the laboratory culture of regeneration-deficient planarians and have established a large live collection with currently > 60 species. Together, these approaches allow us to analyze the molecular mechanisms that orchestrate regeneration in the well regenerating model species, the specific changes in the underlying regulatory networks that cause regeneration defects in other species and finally the evolutionary mechanisms that might explain their natural selection. My talk will illustrate our model taxon approach by example of the Wnt signaling network, which we identified both as core mechanism of normal regeneration and as a hot spot in the repeated evolution of planarian regeneration defects.

Hosted by Romain Levayer

Location

Building: J.Monod (#66)
Room: Monod 7th floor, rooms 2 & 3 a+b
Address: Institut Pasteur, 25 Rue du Docteur Roux, 75015 Paris, France