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© Research
Event

Department seminar by Sally Horne-Badovinac, from the University of Chicago: “Going in circles gets you somewhere: signaling mechanisms that coordinate individual cell movements for collective migration”

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
30
Mar 2018
Time
11:00:00
25 Rue du Dr Roux, Paris, France
Address
Building: Monod Room: Amphi Monod
Location
2018-03-30 11:00:00 2018-03-30 00:00:00 Europe/Paris Department seminar by Sally Horne-Badovinac, from the University of Chicago: “Going in circles gets you somewhere: signaling mechanisms that coordinate individual cell movements for collective migration” The collective migration of cells within an epithelial sheet underlies tissue remodeling events associated with morphogenesis, wound repair, and the metastatic cascade. Yet little is known about how each epithelial cell coordinates its movements […] 25 Rue du Dr Roux, Paris, France Sigolène Meilhac sigolene.meilhac@pasteur.fr

About

The collective migration of cells within an epithelial sheet underlies tissue remodeling events associated with morphogenesis, wound repair, and the metastatic cascade. Yet little is known about how each epithelial cell coordinates its movements with those of its neighbors. Studying the rotational migration of the follicular epithelium in Drosophila, we have identified two signaling pathways that these cells use to coordinate their movements for collective motility. In the first half of the seminar, I will show that the cadherin Fat2 and the receptor tyrosine phosphatase Lar send short-range signals within the tissue plane to coordinate leading edge and trailing edge dynamics between neighboring cells. In the second half of the seminar, I will show that Semaphorin-5c and Plexin A also provide important signals required for collective migration, and that these signals appear to antagonize Fat2-Lar signaling via an unknown mechanism. Interestingly, Fat2, Lar, Semaphorin-5c and Plexin A all play key roles in wiring the nervous system. Thus, the same cues that guide neurites through the body may also be used by epithelial cells to influence the migratory behavior of their neighbors.

Location

Building: Monod
Room: Amphi Monod
Address: 25 Rue du Dr Roux, Paris, France