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© Antoinette Ryter
Serratia marcescens avec présence de flagelles (cils) péritriches. Famille des Enterobacteriaceae, bacille à Gram négatif, non sporulé, anaérobie facultatif, mobile, parfois encapsulé, pouvant synthétiser un pigment rouge ou rose. Présent dans les végétaux , le sol, et l'eau. A l'origine d'infections nosocomiales et résistant à de nombreux antibiotiques. Image colorisée.
Event

Department of Microbiology : “How microbes keep their CRISPR memories functional and up to date”, by Prof Stan J.J. BROUNS

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
28
Sep 2018
Time
11:30:00
28 Rue du Docteur Roux, Paris, France
Address
Building: Centre François Jacob Room: Auditorium Centre François Jacob
Location
2018-09-28 11:30:00 2018-09-28 12:30:00 Europe/Paris Department of Microbiology : “How microbes keep their CRISPR memories functional and up to date”, by Prof Stan J.J. BROUNS The CRISPR immune system protects bacteria and archaea from invading viruses and plasmids. Immunity depends on protein diverse protein complexes that use small RNA molecules to find matching viral or plasmid DNA. I will […] 28 Rue du Docteur Roux, Paris, France

About

The CRISPR immune system protects bacteria and archaea from invading viruses and plasmids. Immunity depends on protein diverse protein complexes that use small RNA molecules to find matching viral or plasmid DNA. I will show how viruses escape immunity by mutating target sites or glycosylating their DNA, and will highlight a mechanism called priming that updates the CRISPR memory leading to rapid co-evolution between host and phage. I will present a new mechanism catalyzed by Cas4 proteins that selects functional CRISPR memories with a PAM (protospacer adjacent motif) that is essential for efficient CRISPR targeting. All of these insights into the biology of CRISPR gathered over the last 10 years have led to some of the most revolutionary molecular genetics tools to date, with Cas9 being the most well known example. I will review some new CRISPR tools for genome engineering approaches and molecular diagnostics.

 

TO PARTICIPATE AT THIS CONFERENCE, PLEASE DO NOT FORGOT TO SHOW YOUR IDENTITY CARD AT THE RECEPTION DESK

Location

Building: Centre François Jacob
Room: Auditorium Centre François Jacob
Address: 28 Rue du Docteur Roux, Paris, France