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© Research
Event

Department of Microbiology and Department of Structural Biology & Chemistry : “Structure and function of the type 6 secretion system, a bacterial weapon of mass destruction”, by Chiara RAPISARDA

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
12
Oct 2018
Time
11:30:00
28 Rue du Docteur Roux, Paris, France
Address
Building: Centre François Jacob Room: Auditorium Centre François Jacob
Location
2018-10-12 11:30:00 2018-10-12 12:30:00 Europe/Paris Department of Microbiology and Department of Structural Biology & Chemistry : “Structure and function of the type 6 secretion system, a bacterial weapon of mass destruction”, by Chiara RAPISARDA The Type VI Secretion System is a well-characterized complex that bacteria use to either defend themselves or to attack other cells, either prokaryotic or eukaryotic. It is composed of a membrane-anchoring complex and a […] 28 Rue du Docteur Roux, Paris, France Nienke Buddelmeijer nienke.buddelmeijer@pasteur.fr

About

The Type VI Secretion System is a well-characterized complex that bacteria use to either defend themselves or to attack other cells, either prokaryotic or eukaryotic. It is composed of a membrane-anchoring complex and a baseplate that allow for the assembly of a tube capped by a spike and surrounded by a helical sheath. When needed, the sheath contracts releasing the tube and the spike with its cargo towards the target cell, leading to its death. The baseplate is a key component of such system, as it not only anchors the tube and sheath to the membrane complex, but also contributes to their assembly.

Here we present the first high-resolution cryo-EM structure of a wedge of the baseplate complex and the membrane complex, and use that structure to model the full secretion system assembly. We also compare the T6SS it to its closest structural homologue of which a high resolution is available, the T4 phage baseplate.

The structure unveils not only potential sites essential for the interaction between components of the system that could be disrupted by targeted antimicrobials, it also provides unprecedented insight into the mechanism of assembly and function of the baseplate and the larger complex of the Type VI Secretion System.

Invited by : Nienke Buddelmeijer (nienke.buddelmeijer@pasteur.fr) & Francesca Gubellini (francesca.gubellini@pasteur.fr)

PLEASE NOTE TO PARTICIPATE AT THIS SEMINAR, YOU MUST SHOW YOUR IDENTITY CARD AT THE RECEPTION DESK

Location

Building: Centre François Jacob
Room: Auditorium Centre François Jacob
Address: 28 Rue du Docteur Roux, Paris, France