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© Matteo Bonazzi, Edith Gouin
Observation en immunofluorescence d'une cellule infectée par Listeria monocytogenes. En bleu: marquage des protéines de surface de Listeria qui permet de visualiser les bactéries. En rouge et vert: marquage de l'actine, une protéine qui forme le cytosquelette des cellules. Les Listeria utilisent l'actine cellulaire pour former des "comêtes" et se déplacer à l'intérieur des cellules qu'elles infectent. Cell infected by Listeria monocytogenes. The surface proteins (in blue) of Listeria enable us to view the bacteria. Actin, a constituent protein of cells, is shown in red and green.
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
24
Oct 2024
Status
Ongoing
Members
3
Structures
3

About

Contactin-associated protein-like 2 (Caspr2) encephalitis is a rare Antibody (Ab)-mediated autoimmune encephalitides (AE). Caspr2-antibdies are associated with a spectrum of neurological core symptoms and signs. The mechanisms by which Caspr2-specific Abs mediate pathology and how Ab-mediated effector functions translate into clinical syndromes and disease progression are incompletely understood. In this project we aim to dissect the relationship between anti-CAspr2 antibody characteristics, disease progression and treatment responses.

Fundings