Timeline

Simon Wain-Hobson

Head of Structure

12 Feb 2016

project

Group for AIDS Research

14 Oct 2014

publication

An avian H7N1 gain-of-function experiment of great concern

09 Oct 2014

publication

APOBEC3A catabolism of electroporated plasmid DNA in mouse muscle

16 Jul 2014

publication

The Irrationality of GOF Avian Influenza Virus Research

01 Apr 2014

publication

Erroneous identification of APOBEC3-edited chromosomal DNA in cancer genomics

24 Oct 2013

publication

Pandemic influenza viruses: time to recognize our inability to predict the unpredictable and stop dangerous gain-of-function experiments

18 Oct 2013

publication

Gain-of-function research: unknown risks

20 Aug 2013

publication

Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death

20 Jun 2013

publication

Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase

28 Mar 2013

publication

H5N1 viral-engineering dangers will not go away

28 Dec 2012

publication

Polymorphic APOBEC3 modulates chronic hepatitis B in Moroccan population

02 Oct 2012

publication

Universal cancer peptide-based therapeutic vaccine breaks tolerance against telomerase and eradicates established tumor

19 Sep 2012

publication

Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1

13 Sep 2012

publication

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A

06 Jun 2012

publication

Structural variability of the herpes simplex virus 1 genome in vitro and in vivo

17 Jan 2012

publication

Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions

12 Oct 2011

publication

Research investment: Vaccine research loses out

01 Jun 2011

publication

Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo

31 Mar 2011

publication

Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1

02 Mar 2011

publication

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

15 Dec 2010

publication

Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines

21 Jul 2010

publication

Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice

28 May 2010

publication

APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo

27 May 2010

publication

Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis

12 May 2010

publication

APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo

21 Oct 2009

publication

Human APOBEC1 cytidine deaminase edits HBV DNA

17 Jun 2009

publication

Oral administration of low doses of plant-based HBsAg induced antigen-specific IgAs and IgGs in mice, without increasing levels of regulatory T cells

12 Mar 2009

publication

Powerful mutators lurking in the genome

26 Jan 2009

publication

Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G

01 Nov 2008

publication

Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo

02 Jul 2008

publication

Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration

30 May 2008

publication

Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs

11 Apr 2008

publication

Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions

14 Feb 2007

publication

Induction of mutations in Drosophila melanogaster gypsy retroelements by modulation of intracellular deoxynucleoside triphosphate pools in vivo

08 Sep 2006

publication

Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication

22 Aug 2006

publication

Optimisation of secretion of recombinant HBsAg virus-like particles: Impact on the development of HIV-1/HBV bivalent vaccines

21 Mar 2006

publication

The HIV-1 clade C promoter is particularly well adapted to replication in the gut in primary infection

01 Mar 2006

publication

Clade-specific differences in active viral replication and compartmentalization

01 Jan 2006

publication

Restriction of foamy viruses by APOBEC cytidine deaminases

01 Dec 2005

publication

The majority of human immunodeficiency virus type 1 particles present within splenic germinal centres are produced locally

01 Sep 2005

publication

Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases

01 Feb 2005

publication

HIV-1 clade promoters strongly influence spatial and temporal dynamics of viral replication in vivo

01 Jan 2005

publication

Recovery of APOBEC3-edited human immunodeficiency virus G->A hypermutants by differential DNA denaturation PCR

15 Dec 2004

publication

A universal primer set for PCR amplification of nuclear histone H4 genes from all animal species

30 Apr 2004

publication

APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase

01 Feb 2004

publication

Simian immunodeficiency virus promoter exchange results in a highly attenuated strain that protects against uncloned challenge virus

01 Oct 2003

publication

Death and the retrovirus

01 Apr 2003

publication

Network analysis of human and simian immunodeficiency virus sequence sets reveals massive recombination resulting in shorter pathways

01 Nov 2002

publication

Identification of a hepatitis B virus genome in wild chimpanzees (Pan troglodytes schweinfurthi) from East Africa indicates a wide geographical dispersion among equatorial African primates

28 May 2002

publication

Analysis of a library of macaque nuclear mitochondrial sequences confirms macaque origin of divergent sequences from old oral polio vaccine samples

01 Apr 2002

publication

Sustained G–>A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome

01 Mar 2002

publication

A little guide for advanced search:

Group for AIDS Research

An avian H7N1 gain-of-function experiment of great concern

APOBEC3A catabolism of electroporated plasmid DNA in mouse muscle

The Irrationality of GOF Avian Influenza Virus Research

Erroneous identification of APOBEC3-edited chromosomal DNA in cancer genomics

Pandemic influenza viruses: time to recognize our inability to predict the unpredictable and stop dangerous gain-of-function experiments

Gain-of-function research: unknown risks

Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death

Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase

H5N1 viral-engineering dangers will not go away

Polymorphic APOBEC3 modulates chronic hepatitis B in Moroccan population

Universal cancer peptide-based therapeutic vaccine breaks tolerance against telomerase and eradicates established tumor

Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A

Structural variability of the herpes simplex virus 1 genome in vitro and in vivo

Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions

Research investment: Vaccine research loses out

Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo

Fitness ranking of individual mutants drives patterns of epistatic interactions in HIV-1

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines

Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice

APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo

Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis

APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo

Human APOBEC1 cytidine deaminase edits HBV DNA

Oral administration of low doses of plant-based HBsAg induced antigen-specific IgAs and IgGs in mice, without increasing levels of regulatory T cells

Powerful mutators lurking in the genome

Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G

Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo

Immunogenicity and tolerance following HIV-1/HBV plant-based oral vaccine administration

Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs

Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions

Induction of mutations in Drosophila melanogaster gypsy retroelements by modulation of intracellular deoxynucleoside triphosphate pools in vivo

Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication

Optimisation of secretion of recombinant HBsAg virus-like particles: Impact on the development of HIV-1/HBV bivalent vaccines

The HIV-1 clade C promoter is particularly well adapted to replication in the gut in primary infection

Clade-specific differences in active viral replication and compartmentalization

Restriction of foamy viruses by APOBEC cytidine deaminases

The majority of human immunodeficiency virus type 1 particles present within splenic germinal centres are produced locally

Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases

HIV-1 clade promoters strongly influence spatial and temporal dynamics of viral replication in vivo

Recovery of APOBEC3-edited human immunodeficiency virus G->A hypermutants by differential DNA denaturation PCR

A universal primer set for PCR amplification of nuclear histone H4 genes from all animal species

APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase

Simian immunodeficiency virus promoter exchange results in a highly attenuated strain that protects against uncloned challenge virus

Death and the retrovirus

Network analysis of human and simian immunodeficiency virus sequence sets reveals massive recombination resulting in shorter pathways

Identification of a hepatitis B virus genome in wild chimpanzees (Pan troglodytes schweinfurthi) from East Africa indicates a wide geographical dispersion among equatorial African primates

Analysis of a library of macaque nuclear mitochondrial sequences confirms macaque origin of divergent sequences from old oral polio vaccine samples

Sustained G–>A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome

Phylogeny derived from coding retroviral genome organization