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© Charles DAUGUET, Institut Pasteur
HIV particles
Publication : The Journal of general virology

The second extracellular loop of CXCR4 is involved in CD4-independent entry of human immunodeficiency virus type 2

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of general virology - 01 Jul 1998

Reeves JD, Heveker N, Brelot A, Alizon M, Clapham PR, Picard L

Link to Pubmed [PMID] – 9680144

J. Gen. Virol. 1998 Jul;79 ( Pt 7):1793-9

Human immunodeficiency virus type 2 (HIV-2) strains that infect cells in the absence of cellular CD4 emerge spontaneously in vitro after culture in CD4+ T-cell lines. The HIV-2ROD/B strain can use the CXCR4 chemokine receptor for efficient entry into CD4+ cells. Here we have shown that the rat homologue of CXCR4, in the absence of CD4, failed to mediate CD4-independent entry by ROD/B. Furthermore, using rat-human chimeric CXCR4 receptors we have demonstrated that the second extracellular loop (E2) of human CXCR4 is critical for HIV-2 infection of CD4+ cells. E2 is also important for HIV-1 infection of CD4+ cells. Our results therefore indicate that the role of E2 in HIV entry is conserved for HIV-1 and HIV-2 and for infection in the presence or absence of CD4.

http://www.ncbi.nlm.nih.gov/pubmed/9680144