Timeline

Pierre Guermonprez

Head of Structure

23 May 2025

publication

Intra-tumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ DC1 infiltration and activates anti-tumor immunity

08 May 2025

publication

The Rab32 small GTPase is required for efficient cross-priming of CD8+ T cells against cell-associated antigens by XCR1+ type 1 DCs in vivo

16 Apr 2025

publication

XCR1+ and IRF4+ migratory dendritic cells cooperate for the cross-priming of intratumoral CD8+ T cells with a tissue-resident memory phenotype

10 Feb 2025

project

Identification de marqueurs moléculaires ou cellulaires modulés par l’immunothérapie dans le mélanome – DENDRINTER (2024-019)

22 May 2024

project

Vaccines coopting dendritic cells to achieve local immunity against respiratory infections.

22 May 2024

project

Cancer immunotherapy by manipulation of the tumour microenvironment of solid tumours.

22 May 2024

project

Instructive role of dendritic cells in the development of T cell memory in the airway.

22 May 2024

project

Dendritic cell-supportive niches in the airway.

22 May 2024

project

Regulation of dendritic cell development from hematopoietic stem cells.

13 Mar 2024

publication

Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors.

19 Dec 2023

publication

FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and NK cell homeostasis.

01 Dec 2023

publication

Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche.

08 Aug 2023

publication

Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors.

28 Mar 2023

team

Dendritic cells and adaptive immunity

01 Jan 2023

publication

In Vitro Generation of Murine Bone Marrow-Derived Dendritic Cells.

01 Jan 2023

publication

In Vitro Generation of Human Dendritic Cell Subsets from CD34+ Cord Blood Progenitors.

31 Mar 2022

publication

Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer.

11 Jan 2022

publication

Epithelial colonization by gut dendritic cells promotes their functional diversification.

14 Apr 2021

publication

TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses.

01 Jan 2021

publication

Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches.

01 Sep 2020

publication

Development and function of human dendritic cells in humanized mice models.

18 Aug 2020

publication

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells.

02 Jun 2020

publication

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses.

28 Apr 2020

publication

Engineered niches support the development of human dendritic cells in humanized mice.

01 Jan 2020

publication

Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses.

01 Jan 2020

publication

Editorial: Monocyte Heterogeneity and Function.

01 Apr 2019

publication

Inflammasome activation: a monocyte lineage privilege.

01 Jan 2019

publication

Origin and development of classical dendritic cells.

23 Aug 2018

publication

The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.

06 Mar 2017

publication

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection.

01 Jan 2017

publication

Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

20 Dec 2016

publication

The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells.

01 Jul 2016

publication

Inducible targeting of cDCs and their subsets in vivo.

01 Jan 2015

publication

Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation.

01 Jan 2015

publication

Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets.

01 Oct 2014

publication

An improved flow cytometry assay to monitor phagosome acidification.

23 Sep 2013

publication

Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium.

04 Jun 2013

publication

Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons.

01 Jun 2013

publication

Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.

01 Nov 2012

publication

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.

27 Aug 2012

publication

Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.

04 Jun 2012

publication

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.

15 Sep 2010

publication

Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes.

01 Jan 2010

publication

Measuring pH, ROS production, maturation, and degradation in dendritic cell phagosomes using cytofluorometry-based assays.

21 Aug 2009

publication

A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells.

10 Jul 2009

publication

IRAP identifies an endosomal compartment required for MHC class I cross-presentation.

17 Apr 2009

publication

In vivo analysis of dendritic cell development and homeostasis.

01 Jun 2008

publication

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.

01 Mar 2008

publication

Selection of an antibody library identifies a pathway to induce immunity by targeting CD36 on steady-state CD8 alpha+ dendritic cells.

01 Jan 2008

publication

Neonatal and adult microglia cross-present exogenous antigens.

15 Oct 2007

publication

Neutrophils efficiently cross-prime naive T cells in vivo.

01 Feb 2007

publication

Antigen presentation by B lymphocytes: how receptor signaling directs membrane trafficking.

14 Jul 2006

publication

NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.

01 Jan 2005

publication

Pathways for antigen cross presentation.

24 Dec 2004

publication

Benznidazole, a drug used in Chagas’ disease, ameliorates LPS-induced inflammatory response in mice.

01 Feb 2004

publication

Control of cross-presentation during dendritic cell maturation.

25 Sep 2003

publication

ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells.

01 Nov 2002

publication

In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells.

01 Feb 2002

publication

Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunity.

01 Jan 2002

publication

Antigen presentation and T cell stimulation by dendritic cells.

07 May 2001

publication

The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18).

01 Jun 2000

publication

Immune responses induced by recombinant BCG strains according to level of production of a foreign antigen: malE.

01 Jan 2000

publication

Bordetella pertussis adenylate cyclase toxin: a vehicle to deliver CD8-positive T-cell epitopes into antigen-presenting cells.

01 Jan 2000

publication

Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites.

01 Nov 1999

publication

mAb against hen egg-white lysozyme regulate its presentation to CD4(+) T cells.

15 Feb 1999

publication

Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway.

01 Nov 1998

publication

A little guide for advanced search:

Intra-tumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1+ DC1 infiltration and activates anti-tumor immunity

The Rab32 small GTPase is required for efficient cross-priming of CD8+ T cells against cell-associated antigens by XCR1+ type 1 DCs in vivo

XCR1+ and IRF4+ migratory dendritic cells cooperate for the cross-priming of intratumoral CD8+ T cells with a tissue-resident memory phenotype

Identification de marqueurs moléculaires ou cellulaires modulés par l’immunothérapie dans le mélanome – DENDRINTER (2024-019)

Vaccines coopting dendritic cells to achieve local immunity against respiratory infections.

Cancer immunotherapy by manipulation of the tumour microenvironment of solid tumours.

Instructive role of dendritic cells in the development of T cell memory in the airway.

Dendritic cell-supportive niches in the airway.

Regulation of dendritic cell development from hematopoietic stem cells.

Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors.

FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and NK cell homeostasis.

Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche.

Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors.

Dendritic cells and adaptive immunity

In Vitro Generation of Murine Bone Marrow-Derived Dendritic Cells.

In Vitro Generation of Human Dendritic Cell Subsets from CD34+ Cord Blood Progenitors.

Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer.

Epithelial colonization by gut dendritic cells promotes their functional diversification.

TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses.

Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches.

Development and function of human dendritic cells in humanized mice models.

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells.

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses.

Engineered niches support the development of human dendritic cells in humanized mice.

Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses.

Editorial: Monocyte Heterogeneity and Function.

Inflammasome activation: a monocyte lineage privilege.

Origin and development of classical dendritic cells.

The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection.

Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells.

Inducible targeting of cDCs and their subsets in vivo.

Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation.

Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets.

An improved flow cytometry assay to monitor phagosome acidification.

Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium.

Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons.

Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.

Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.

Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes.

Measuring pH, ROS production, maturation, and degradation in dendritic cell phagosomes using cytofluorometry-based assays.

A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells.

IRAP identifies an endosomal compartment required for MHC class I cross-presentation.

In vivo analysis of dendritic cell development and homeostasis.

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.

Selection of an antibody library identifies a pathway to induce immunity by targeting CD36 on steady-state CD8 alpha+ dendritic cells.

Neonatal and adult microglia cross-present exogenous antigens.

Neutrophils efficiently cross-prime naive T cells in vivo.

Antigen presentation by B lymphocytes: how receptor signaling directs membrane trafficking.

NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.

Pathways for antigen cross presentation.

Benznidazole, a drug used in Chagas’ disease, ameliorates LPS-induced inflammatory response in mice.

Control of cross-presentation during dendritic cell maturation.

ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells.

In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells.

Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunity.

Antigen presentation and T cell stimulation by dendritic cells.

The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18).

Immune responses induced by recombinant BCG strains according to level of production of a foreign antigen: malE.

Bordetella pertussis adenylate cyclase toxin: a vehicle to deliver CD8-positive T-cell epitopes into antigen-presenting cells.

Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites.

mAb against hen egg-white lysozyme regulate its presentation to CD4(+) T cells.

Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway.

The rate of dissociation between antibody and antigen determines the efficiency of antibody-mediated antigen presentation to T cells.