Ligne de temps

Pierre Guermonprez

Responsable de Structure

13 mars 2024

publication

Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors.

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19 déc. 2023

publication

FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and NK cell homeostasis.

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01 déc. 2023

publication

Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche.

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08 août 2023

publication

Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors.

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28 mars 2023

team

Cellules dendritiques et immunité adaptative

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01 janv. 2023

publication

In Vitro Generation of Murine Bone Marrow-Derived Dendritic Cells.

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01 janv. 2023

publication

In Vitro Generation of Human Dendritic Cell Subsets from CD34+ Cord Blood Progenitors.

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31 mars 2022

publication

Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer.

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11 janv. 2022

publication

Epithelial colonization by gut dendritic cells promotes their functional diversification.

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14 avr. 2021

publication

TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses.

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01 janv. 2021

publication

Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches.

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01 sept. 2020

publication

Development and function of human dendritic cells in humanized mice models.

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18 août 2020

publication

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells.

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02 juin 2020

publication

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses.

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28 avr. 2020

publication

Engineered niches support the development of human dendritic cells in humanized mice.

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01 janv. 2020

publication

Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses.

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01 janv. 2020

publication

Editorial: Monocyte Heterogeneity and Function.

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01 avr. 2019

publication

Inflammasome activation: a monocyte lineage privilege.

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01 janv. 2019

publication

Origin and development of classical dendritic cells.

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23 août 2018

publication

The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.

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06 mars 2017

publication

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection.

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01 janv. 2017

publication

Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

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20 déc. 2016

publication

The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells.

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01 juil. 2016

publication

Inducible targeting of cDCs and their subsets in vivo.

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01 janv. 2015

publication

Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation.

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01 janv. 2015

publication

Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets.

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01 oct. 2014

publication

An improved flow cytometry assay to monitor phagosome acidification.

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23 sept. 2013

publication

Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium.

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04 juin 2013

publication

Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons.

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01 juin 2013

publication

Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.

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01 nov. 2012

publication

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.

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27 août 2012

publication

Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.

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04 juin 2012

publication

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.

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15 sept. 2010

publication

Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes.

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01 janv. 2010

publication

Measuring pH, ROS production, maturation, and degradation in dendritic cell phagosomes using cytofluorometry-based assays.

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21 août 2009

publication

A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells.

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10 juil. 2009

publication

IRAP identifies an endosomal compartment required for MHC class I cross-presentation.

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17 avr. 2009

publication

In vivo analysis of dendritic cell development and homeostasis.

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01 juin 2008

publication

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.

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01 mars 2008

publication

Selection of an antibody library identifies a pathway to induce immunity by targeting CD36 on steady-state CD8 alpha+ dendritic cells.

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01 janv. 2008

publication

Neonatal and adult microglia cross-present exogenous antigens.

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15 oct. 2007

publication

Neutrophils efficiently cross-prime naive T cells in vivo.

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01 févr. 2007

publication

Antigen presentation by B lymphocytes: how receptor signaling directs membrane trafficking.

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14 juil. 2006

publication

NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.

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01 janv. 2005

publication

Pathways for antigen cross presentation.

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24 déc. 2004

publication

Benznidazole, a drug used in Chagas’ disease, ameliorates LPS-induced inflammatory response in mice.

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01 févr. 2004

publication

Control of cross-presentation during dendritic cell maturation.

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25 sept. 2003

publication

ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells.

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01 nov. 2002

publication

In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells.

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01 févr. 2002

publication

Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunity.

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01 janv. 2002

publication

Antigen presentation and T cell stimulation by dendritic cells.

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07 mai 2001

publication

The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18).

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01 juin 2000

publication

Immune responses induced by recombinant BCG strains according to level of production of a foreign antigen: malE.

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01 janv. 2000

publication

Bordetella pertussis adenylate cyclase toxin: a vehicle to deliver CD8-positive T-cell epitopes into antigen-presenting cells.

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01 janv. 2000

publication

Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites.

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01 nov. 1999

publication

mAb against hen egg-white lysozyme regulate its presentation to CD4(+) T cells.

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15 févr. 1999

publication

Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway.

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01 nov. 1998

publication

The rate of dissociation between antibody and antigen determines the efficiency of antibody-mediated antigen presentation to T cells.

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Un petit guide pour l'utilisation de la recherche avancée :

Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors.

FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and NK cell homeostasis.

Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche.

Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors.

Cellules dendritiques et immunité adaptative

In Vitro Generation of Murine Bone Marrow-Derived Dendritic Cells.

In Vitro Generation of Human Dendritic Cell Subsets from CD34+ Cord Blood Progenitors.

Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer.

Epithelial colonization by gut dendritic cells promotes their functional diversification.

TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses.

Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches.

Development and function of human dendritic cells in humanized mice models.

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells.

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses.

Engineered niches support the development of human dendritic cells in humanized mice.

Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses.

Editorial: Monocyte Heterogeneity and Function.

Inflammasome activation: a monocyte lineage privilege.

Origin and development of classical dendritic cells.

The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.

Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection.

Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.

The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells.

Inducible targeting of cDCs and their subsets in vivo.

Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation.

Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets.

An improved flow cytometry assay to monitor phagosome acidification.

Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium.

Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons.

Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.

Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.

Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes.

Measuring pH, ROS production, maturation, and degradation in dendritic cell phagosomes using cytofluorometry-based assays.

A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells.

IRAP identifies an endosomal compartment required for MHC class I cross-presentation.

In vivo analysis of dendritic cell development and homeostasis.

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.

Selection of an antibody library identifies a pathway to induce immunity by targeting CD36 on steady-state CD8 alpha+ dendritic cells.

Neonatal and adult microglia cross-present exogenous antigens.

Neutrophils efficiently cross-prime naive T cells in vivo.

Antigen presentation by B lymphocytes: how receptor signaling directs membrane trafficking.

NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.

Pathways for antigen cross presentation.

Benznidazole, a drug used in Chagas’ disease, ameliorates LPS-induced inflammatory response in mice.

Control of cross-presentation during dendritic cell maturation.

ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells.

In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells.

Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunity.

Antigen presentation and T cell stimulation by dendritic cells.

The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18).

Immune responses induced by recombinant BCG strains according to level of production of a foreign antigen: malE.

Bordetella pertussis adenylate cyclase toxin: a vehicle to deliver CD8-positive T-cell epitopes into antigen-presenting cells.

Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites.

mAb against hen egg-white lysozyme regulate its presentation to CD4(+) T cells.

Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway.

The rate of dissociation between antibody and antigen determines the efficiency of antibody-mediated antigen presentation to T cells.