Timeline
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Timothy Wai
Head of Structure
11 Jun 2024
publication
Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling.
Read more11 Jun 2024
20 Dec 2023
news
New publication – Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis
Read more20 Dec 2023
publication
Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis.
Read more10 Oct 2023
project
MitoDeath: Dissecting the molecular mechanisms responsible for a mitochondrial defect leading to motor neuron death (FRM)
Read more10 Oct 2023
project
IMHOTEP: Role of hepatocyte mitochondrial dysfunction in the occurrence and progression of NAFLD (ANR)
Read more10 Oct 2023
project
MitoCure: Mitochondrial Disease Platform-Institut Pasteur (ArgoBIO et Institut Pasteur)
Read more01 Mar 2023
publication
MPC2 variants disrupt mitochondrial pyruvate metabolism and cause an early-onset mitochondriopathy.
Read more20 Feb 2023
01 Feb 2023
01 Feb 2023
event
BCI Seminar – “Deciphering the spatiotemporal and mechanical regulation of integrin and actin regulators at the nanoscale”
Read more03 Jan 2023
news
New publication – Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure
Read more01 Jan 2023
publication
Mitochondrial dynamics and metabolic regulation control T cell fate in the thymus.
Read more04 Nov 2022
publication
Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure.
Read more21 Oct 2022
publication
CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viability.
Read more09 May 2022
event
Combination of spectroscopy with microscopy enables new dimensions in quantitative biology – Leonel Malacrida, IP Montevideo
Read more06 Apr 2022
09 Nov 2021
publication
Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling.
Read more18 Oct 2021
04 Oct 2021
publication
Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A.
Read more07 Jun 2021
publication
High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts.
Read more27 May 2021
news
Mitochondrial diseases: a new screening leads to insight on the effect of various genes on DOA
Read more01 May 2021
05 Apr 2021
01 Jan 2021
publication
Mitochondrial Nucleic Acid as a Driver of Pathogenic Type I Interferon Induction in Mendelian Disease.
Read more26 Aug 2019
event
BCI Seminar – “Cytoskeletal cross-talk with integrin adhesion complexes in cell morphogenesis”
Read more01 Jan 2019
publication
Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.
Read more03 Jun 2018
01 Jun 2018
01 Aug 2017
publication
Lung ultrasound as a translational approach for non-invasive assessment of heart failure with reduced or preserved ejection fraction in mice
Read more13 Oct 2016
publication
The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L
Read more06 Aug 2016
publication
Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation
Read more02 Jan 2016
04 Dec 2015
publication
Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice
Read more06 Aug 2015
publication
SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation
Read more16 Mar 2015
publication
Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function
Read more12 Feb 2015
publication
The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis
Read more10 Mar 2014
publication
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
Read more06 Aug 2013
publication
TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid
Read more07 Oct 2012
publication
Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission
Read more14 Oct 2010
03 Mar 2010
publication
LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria
Read more03 Feb 2010
01 Dec 2008
publication
The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes
Read more15 Feb 2008
01 Jan 2007
09 Jun 2006
publication
A hemizygous SCO2 mutation in an early onset rapidly progressive, fatal cardiomyopathy
Read more01 Dec 2004
publication
Mutations in the MMAA gene in patients with the cblA disorder of vitamin B12 metabolism
Read more15 Dec 2002
publication