Ligne de temps
Patrick England
Responsable de Plateforme
30 janv. 2025
publication
Antibody-secreting cell repertoires hold high-affinity anti-rocuronium specificities that can induce anaphylaxis in vivo.
Lire plus30 déc. 2024
publication
Communication between DNA polymerases and Replication Protein A within the archaeal replisome.
Lire plus11 sept. 2024
publication
Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models.
Lire plus19 janv. 2024
08 janv. 2024
publication
Interrogating Aptamer Chemical Space Through Modified Nucleotide Substitution Facilitated by Enzymatic DNA Synthesis
Lire plus06 janv. 2024
publication
PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial.
Lire plus04 janv. 2024
publication
Antigen self-anchoring onto bacteriophage T5 capsid-like particles for vaccine design
Lire plus01 janv. 2024
publication
Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology.
Lire plus04 déc. 2023
05 oct. 2023
publication
The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin.
Lire plus25 sept. 2023
publication
An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies.
Lire plus21 août 2023
publication
New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex
Lire plus01 août 2023
11 mai 2023
publication
The cell wall lipoprotein CD1687 acts as a DNA binding protein during deoxycholate-induced biofilm formation in Clostridioides difficile.
Lire plus11 janv. 2023
publication
The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae.
Lire plus28 juin 2022
publication
Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery.
Lire plus24 mai 2022
publication
Dengue virus NS1 protein conveys pro-inflammatory signals by docking onto high-density lipoproteins.
Lire plus03 mai 2022
publication
High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura.
Lire plus12 févr. 2022
publication
Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Lire plus09 déc. 2021
publication
The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses.
Lire plus26 nov. 2021
event
1st MOSBRI Scientific Conference – Physical meeting at Institut Pasteur Paris – June 20-22, 2022
Lire plus21 juil. 2021
publication
SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction.
Lire plus04 juin 2021
publication
SepF is the FtsZ anchor in archaea, with features of an ancestral cell division system
Lire plus01 juin 2020
publication
High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics
Lire plus27 mars 2020
publication
Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.
Lire plus30 janv. 2020
publication
Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein.
Lire plus06 déc. 2019
publication
X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications.
Lire plus26 sept. 2018
publication
An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins
Lire plus01 sept. 2018
publication
An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins
Lire plus29 mars 2018
01 mars 2018
publication
Biophysical Approaches to Protein Folding and Disease, a satellite meeting to the IUPAB-EBSA congress
Lire plus15 janv. 2018
publication
The stress sigma factor of RNA polymerase RpoS/σ is a solvent-exposed open molecule in solution
Lire plus12 janv. 2018
publication
Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough.
Lire plus13 déc. 2017
event
Prof. BÜLL Alexander “Insights into the mechanism of amyloid fibril formation by alpha-synuclein”
Lire plus05 déc. 2017
14 nov. 2017
03 nov. 2017
publication
A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion.
Lire plus11 sept. 2017
publication
Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring
Lire plus01 août 2017
publication
Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery
Lire plus13 juin 2017
publication
Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening
Lire plus16 mai 2017
publication
Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2
Lire plus05 mai 2017
28 avr. 2017
publication
Erratum: High affinity anchoring of the decoration protein pb10 onto the bacteriophage T5 capsid
Lire plus06 févr. 2017
publication
High affinity anchoring of the decoration protein pb10 onto the bacteriophage T5 capsid
Lire plus27 janv. 2017
10 nov. 2016
publication
Erratum: Structural basis of potent Zika-dengue virus antibody cross-neutralization.
Lire plus01 oct. 2016
publication
Mechanistic Insight into Bunyavirus-Induced Membrane Fusion from Structure-Function Analyses of the Hantavirus Envelope Glycoprotein Gc.
Lire plus13 sept. 2016
publication
Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes
Lire plus18 août 2016
publication
Correction: The Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pH
Lire plus30 juil. 2016
publication
Efficient monitoring of protein ubiquitylation levels using TUBEs-based microarrays
Lire plus23 juin 2016
26 avr. 2016
20 avr. 2016
12 avr. 2016
publication
The Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pH
Lire plus27 mars 2016
25 mars 2016
publication
The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation
Lire plus01 janv. 2016
publication
Real-Time Surface Plasmon Resonance (SPR) for the Analysis of Interactions Between SUMO Traps and Mono- or PolySUMO Moieties
Lire plus20 nov. 2015
project
Biophysical characterization of the translocation process of Bordetella pertussis adenylate cyclase toxin CyaA
Lire plus23 oct. 2015
publication
The Stable Interaction Between Signal Peptidase LepB of Escherichia coli and Nuclease Bacteriocins Promotes Toxin Entry into the Cytoplasm
Lire plus12 sept. 2015
17 août 2015
05 août 2015
publication
A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of Human Respiratory Syncytial Virus
Lire plus13 mai 2015
publication
The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid
Lire plus17 mars 2015
publication
A Residue Quartet in the Extracellular Domain of the Prolactin Receptor Selectively Controls Mitogen-activated Protein Kinase Signaling
Lire plus17 févr. 2015
07 janv. 2015
publication
Identification and characterization of the binding site of the respiratory syncytial virus phosphoprotein to RNA-free nucleoprotein.
Lire plus01 janv. 2015
publication
A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.
Lire plus30 déc. 2014
15 déc. 2014
publication
Residue 146 regulates prolactin receptor folding, basal activity and ligand-responsiveness: potential implications in breast tumorigenesis
Lire plus03 déc. 2014
publication
Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein E2 recognized by broadly neutralizing antibodies
Lire plus15 oct. 2014
publication
Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase
Lire plus11 avr. 2014
publication
Interaction of a partially disordered antisigma factor with its partner, the signaling domain of the TonB-dependent transporter HasR
Lire plus18 nov. 2013
30 avr. 2013
18 mars 2013
publication
SUN proteins belong to a novel family of β-(1,3)-glucan-modifying enzymes involved in fungal morphogenesis
Lire plus30 janv. 2013
publication
The α-helical regions of KERP1 are important in Entamoeba histolytica adherence to human cells
Lire plus04 janv. 2013
publication
The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy
Lire plus01 janv. 2013
13 sept. 2012
publication
Citrullination of histone H3 interferes with HP1-mediated transcriptional repression
Lire plus26 mars 2012
publication
Transglutaminase is essential for IgA nephropathy development acting through IgA receptors
Lire plus09 déc. 2011
publication
Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands
Lire plus21 nov. 2011
publication
Pilotin-secretin recognition in the type II secretion system of Klebsiella oxytoca
Lire plus15 sept. 2011
publication
Characterization of the elongasome core PBP2 : MreC complex of Helicobacter pylori
Lire plus01 juil. 2011
publication
Insights into the Rrf2 repressor family–the structure of CymR, the global cysteine regulator of Bacillus subtilis
Lire plus14 mars 2011
publication
Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition
Lire plus01 déc. 2010
publication
Calcium-induced folding and stabilization of the intrinsically disordered RTX domain of the CyaA toxin
Lire plus08 oct. 2010
publication
Crl binds to domain 2 of σ(S) and confers a competitive advantage on a natural rpoS mutant of Salmonella enterica serovar Typhi
Lire plus16 juil. 2010
publication
Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids
Lire plus01 avr. 2010
publication
AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX
Lire plus19 févr. 2010
publication
The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule
Lire plus02 oct. 2009
publication
Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities
Lire plus18 août 2009
publication
Novel svVEGF isoforms from Macrovipera lebetina venom interact with neuropilins
Lire plus27 nov. 2008
18 nov. 2008
publication
Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses
Lire plus23 oct. 2008
publication
FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation
Lire plus18 oct. 2008
publication
Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation
Lire plus25 sept. 2008
publication
Binding of the unorthodox transcription activator, Crl, to the components of the transcription machinery
Lire plus04 sept. 2007
publication
Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL
Lire plus14 août 2007
publication
Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential.
Lire plus08 juin 2007
publication
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity
Lire plus01 juin 2007
publication
Clostridium difficile toxin expression is inhibited by the novel regulator TcdC
Lire plus07 févr. 2007
publication
Rabies virus matrix protein interplay with eIF3, new insights into rabies virus pathogenesis
Lire plus15 août 2006
publication
Peroxynitrite transforms nerve growth factor into an apoptotic factor for motor neurons
Lire plus25 avr. 2006
publication
Characterization of the non-native trifluoroethanol-induced intermediate conformational state of the Shiga toxin B-subunit
Lire plus01 janv. 2006
publication
The scc spirochetal coiled-coil protein forms helix-like filaments and binds to nucleic acids generating nucleoprotein structures
Lire plus01 janv. 2006
publication
Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus
Lire plus01 sept. 2005
publication
Stable trimerization of recombinant rabies virus glycoprotein ectodomain is required for interaction with the p75NTR receptor
Lire plus24 févr. 2005
publication
Energetics of 5-bromo-4-chloro-3-indolyl-alpha-D-mannose binding to the Parkia platycephala seed lectin and its use for MAD phasing
Lire plus29 juil. 2004
publication
Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.
Lire plus23 avr. 2004
publication
Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3
Lire plus20 févr. 2004
publication
A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor
Lire plus30 oct. 2003
publication
A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients
Lire plus07 juil. 2003
publication
The N-terminal domain of hepatocyte growth factor inhibits the angiogenic behavior of endothelial cells independently from binding to the c-met receptor
Lire plus01 sept. 2002
01 août 2002
publication
Several regions of the repeat domain of the Staphylococcus caprae autolysin, AtlC, are involved in fibronectin binding
Lire plus26 avr. 2002
publication
Knowledge-based design of reagentless fluorescent biosensors from recombinant antibodies
Lire plus01 nov. 1998
publication