Ligne de temps
Hugues Aschard
Responsable de Structure
10 avr. 2024
event
Dpt of Computational Biology seminar “Methods Primer” – Christian Vestergaard (IP, Paris)
Lire plus10 avr. 2024
10 avr. 2024
event
Dpt of Computational Biology seminar “Methods Primer” – Jean-Baptiste Masson (IP Paris)
Lire plus09 janv. 2024
project
Construction d’un score d’information génétique pour faciliter la sélection de cible thérapeutique
Lire plus17 juin 2022
project
Étude des facteurs génétiques et cliniques prédictifs de la variabilité du microbiome et leur rôle dans les maladies inflammatoires de l’intestin (projet MicMat)
Lire plus01 juin 2022
06 janv. 2022
publication
Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort.
Lire plus01 déc. 2021
23 nov. 2021
publication
Powerful gene-based testing by integrating long-range chromatin interactions and knockoff genotypes.
Lire plus01 nov. 2021
publication
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
Lire plus01 août 2021
publication
Genetic meta-analysis of cancer diagnosis following statin use identifies new associations and implicates human leukocyte antigen (HLA) in women.
Lire plus01 août 2021
30 juin 2021
01 juin 2021
publication
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.
Lire plus01 juin 2021
publication
Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption: A Gene-Diet Interaction Study from the UK Biobank.
Lire plus24 mars 2021
24 mars 2021
18 mars 2021
publication
Estimating the effective sample size in association studies of quantitative traits.
Lire plus14 janv. 2021
publication
Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits.
Lire plus08 déc. 2020
publication
Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis.
Lire plus18 juin 2020
publication
Deriving stratified effects from joint models investigating gene-environment interactions.
Lire plus01 mai 2020
publication
Mixed-model admixture mapping identifies smoking-dependent loci of lung function in African Americans.
Lire plus01 mars 2020
07 janv. 2020
publication
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes
Lire plus05 déc. 2019
12 nov. 2019
publication
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.
Lire plus01 nov. 2019
21 oct. 2019
publication
A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context.
Lire plus01 oct. 2019
publication
Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.
Lire plus01 sept. 2019
publication
A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.
Lire plus01 août 2019
publication
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.
Lire plus01 juin 2019
publication
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.
Lire plus01 mai 2019
29 avr. 2019
01 avr. 2019
publication
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Lire plus01 avr. 2019
publication
Adjusting for Principal Components of Molecular Phenotypes Induces Replicating False Positives.
Lire plus01 mars 2019
publication
Genetic effects on the commensal microbiota in inflammatory bowel disease patients.
Lire plus01 févr. 2019
publication
Joint Analysis of Multiple Interaction Parameters in Genetic Association Studies.
Lire plus22 janv. 2019
publication
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
Lire plus18 déc. 2018
publication
Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation.
Lire plus01 oct. 2018
15 août 2018
publication
Efficient analysis of large-scale genome-wide data with two R packages: bigstatsr and bigsnpr.
Lire plus27 juil. 2018
publication
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.
Lire plus19 juil. 2018
01 avr. 2018
publication
A test for gene-environment interaction in the presence of measurement error in the environmental variable.
Lire plus01 mars 2018
publication
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
Lire plus27 févr. 2018
publication
lme4qtl: linear mixed models with flexible covariance structure for genetic studies of related individuals.
Lire plus01 févr. 2018
publication
Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets.
Lire plus01 févr. 2018
17 janv. 2018
publication
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
Lire plus16 janv. 2018
publication
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.
Lire plus01 janv. 2018
publication
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
Lire plus01 déc. 2017
publication
Covariate selection for association screening in multiphenotype genetic studies.
Lire plus01 nov. 2017
publication
Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis.
Lire plus01 oct. 2017
publication
Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases.
Lire plus01 oct. 2017
publication
Update on the State of the Science for Analytical Methods for Gene-Environment Interactions.
Lire plus01 oct. 2017
publication
Incorporation of Biological Knowledge Into the Study of Gene-Environment Interactions.
Lire plus01 juin 2017
publication
Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.
Lire plus01 juin 2017
01 mars 2017
publication
Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.
Lire plus01 févr. 2017
publication
Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample.
Lire plus01 janv. 2017
01 janv. 2017
publication
A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts.
Lire plus15 déc. 2016
publication
Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms.
Lire plus01 déc. 2016
01 oct. 2016
publication
Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.
Lire plus29 sept. 2016
01 sept. 2016
publication
Genomics, Telomere Length, Epigenetics, and Metabolomics in the Nurses’ Health Studies.
Lire plus01 juil. 2016
publication
An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group.
Lire plus18 mai 2016
publication
Power Calculation of Multi-step Combined Principal Components with Applications to Genetic Association Studies
Lire plus01 avr. 2016
publication
Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans.
Lire plus04 févr. 2016
01 févr. 2016
publication
Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.
Lire plus24 oct. 2015
publication
Leveraging local ancestry to detect gene-gene interactions in genome-wide data.
Lire plus01 oct. 2015
publication
[Genetic and environmental factors of asthma and allergy: Results of the EGEA study].
Lire plus22 juil. 2015
01 mai 2015
05 févr. 2015
publication
Adjusting for heritable covariates can bias effect estimates in genome-wide association studies.
Lire plus01 janv. 2015
publication
Variation in predictive ability of common genetic variants by established strata: the example of breast cancer and age.
Lire plus01 mai 2014
publication
Maximizing the power of principal-component analysis of correlated phenotypes in genome-wide association studies.
Lire plus17 déc. 2013
publication
Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing.
Lire plus01 déc. 2013
publication
Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study.
Lire plus01 mai 2013
publication
A nonparametric test to detect quantitative trait loci where the phenotypic distribution differs by genotypes.
Lire plus02 janv. 2013
publication
Transcriptional response of mucoid Pseudomonas aeruginosa to human respiratory mucus.
Lire plus01 janv. 2013
publication
A comprehensive analysis of in vitro and in vivo genetic fitness of Pseudomonas aeruginosa using high-throughput sequencing of transposon libraries.
Lire plus01 janv. 2013
publication
Exploring genome-wide – dietary heme iron intake interactions and the risk of type 2 diabetes.
Lire plus01 oct. 2012
publication
Challenges and opportunities in genome-wide environmental interaction (GWEI) studies.
Lire plus08 juin 2012
publication
Inclusion of gene-gene and gene-environment interactions unlikely to dramatically improve risk prediction for complex diseases.
Lire plus01 janv. 2012
publication
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
Lire plus29 nov. 2011
publication
Combining effects from rare and common genetic variants in an exome-wide association study of sequence data.
Lire plus01 janv. 2011
publication
Inflated type I error rates when using aggregation methods to analyze rare variants in the 1000 Genomes Project exon sequencing data in unrelated individuals: summary results from Group 7 at Genetic Analysis Workshop 17
Lire plus01 juil. 2010
publication
17q21 variants modify the association between early respiratory infections and asthma.
Lire plus01 janv. 2010
publication
Genome-wide meta-analysis of joint tests for genetic and gene-environment interaction effects.
Lire plus01 sept. 2009
publication
Sex-specific effect of IL9 polymorphisms on lung function and polysensitization.
Lire plus06 nov. 2008
01 janv. 2007
01 janv. 2007
publication