Ligne de temps

22 juil. 2021

publication

Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.

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18 nov. 2019

event

PhD thesis defense Morgane Grand

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22 août 2017

publication

Immunological memory to blood-stage malaria infection is controlled by the histamine releasing factor (HRF) of the parasite

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09 févr. 2017

publication

The antimicrobial molecule trappin-2/elafin has anti-parasitic properties and is protective in vivo in a murine model of cerebral malaria

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23 févr. 2016

publication

Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites

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25 août 2015

publication

Risk factors associated with asthma, atopic dermatitis and rhinoconjunctivitis in a rural Senegalese cohort

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08 juil. 2015

project

P. berghei, a rodent malaria model to investigate host-parasite interactions central for malaria pathogenesis

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27 avr. 2015

publication

Disruption of Parasite hmgb2 Gene Attenuates Plasmodium berghei ANKA Pathogenicity

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22 nov. 2014

publication

Plasmodium berghei histamine-releasing factor favours liver-stage development via inhibition of IL-6 production and associates with a severe outcome of disease

Lire plus

26 juil. 2013

publication

Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis

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24 sept. 2012

publication

Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

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22 juin 2012

publication

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

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01 juin 2012

publication

Impact of mosquito bites on asexual parasite density and gametocyte prevalence in asymptomatic chronic Plasmodium falciparum infections and correlation with IgE and IgG titers.

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16 mars 2012

publication

Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells

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23 déc. 2011

publication

Duality and complexity of allergic type inflammatory mechanisms in determining the outcome of malaria disease

Lire plus

03 oct. 2011

publication

Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria

Lire plus

02 juin 2011

publication

Downregulation of basophil-derived IL-4 and in vivo T(H)2 IgE responses by serotonin and other organic cation transporter 3 ligands

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11 mars 2011

publication

Anopheles stephensi saliva enhances progression of cerebral malaria in a murine model

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23 févr. 2011

publication

Contribution of allergic inflammatory response to the pathogenesis of malaria disease

Lire plus

30 déc. 2010

publication

Human and mouse mast cells express and secrete the GPI-anchored isoform of CD160

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03 sept. 2010

publication

Strain-transcendent immune response to recombinant Var2CSA DBL5-ε domain block P. falciparum adhesion to placenta-derived BeWo cells under flow conditions

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23 juin 2009

publication

Histamine H(3) receptor-mediated signaling protects mice from cerebral malaria

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01 avr. 2009

publication

[Role of histamine and histamine receptors in the pathogenesis of malaria]

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28 janv. 2008

publication

Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease

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04 janv. 2007

publication

Total and functional parasite specific IgE responses in Plasmodium falciparum-infected patients exhibiting different clinical status

Lire plus

01 avr. 2006

publication

Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites

Lire plus

01 mai 2005

publication

Comparison of the allergenic potency of spores and mycelium of Cladosporium

Lire plus

01 avr. 2005

publication

Anopheles mosquito bites activate cutaneous mast cells leading to a local inflammatory response and lymph node hyperplasia

Lire plus

01 août 2004

publication

Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects

Lire plus

01 oct. 2003

publication

Human serum IgE-mediated mast cell degranulation shows poor correlation to allergen-specific IgE content

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01 mai 2003

publication

[Immunological and non immunological mechanisms in urticaria]

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15 mars 2003

publication

Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo

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01 sept. 2002

publication

Immunoregulatory properties of mast cell-derived exosomes

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01 févr. 2001

publication

Capacity of mouse mast cells to prime T cells and to induce specific antibody responses in vivo

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15 janv. 2001

publication

Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes

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01 janv. 2001

publication

Nonspecific B and T cell-stimulatory activity mediated by mast cells is associated with exosomes

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01 janv. 2000

publication

In vitro and in vivo immunostimulatory potential of bone marrow-derived mast cells on B- and T-lymphocyte activation

Lire plus

01 juin 1999

publication

FcepsilonRI-mediated antigen endocytosis turns interferon-gamma-treated mouse mast cells from inefficient into potent antigen-presenting cells

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01 déc. 1998

publication

Expression of functional major histocompatibility complex class II molecules on HMC-1 human mast cells

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01 juil. 1998

publication

Specific antigen targeting to surface IgE and IgG on mouse bone marrow-derived mast cells enhances efficiency of antigen presentation

Lire plus

01 mars 1998

publication

IL-4 mRNA transcription is induced in mouse bone marrow-derived mast cells through an MHC class II-dependent signaling pathway

Lire plus

01 déc. 1997

publication

Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation

Lire plus

01 juin 1997

publication

Functional analysis of Mycoplasma arthritidis-derived mitogen interactions with class II molecules

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01 mai 1997

publication

Unravelling the mast cell dilemma: culprit or victim of its generosity?

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01 oct. 1996

publication

Exogenous and endogenous antigens are differentially presented by mast cells to CD4+ T lymphocytes

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15 août 1996

publication

Mouse bone marrow-derived mast cells and mast cell lines constitutively produce B cell growth and differentiation activities

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01 juin 1995

publication

Presentation of soluble antigens by mast cells: upregulation by interleukin-4 and granulocyte/macrophage colony-stimulating factor and downregulation by interferon-gamma

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01 nov. 1994

publication

Modulation of Mycoplasma arthritidis-derived superantigen-induced cytokine gene expression by dexamethasone and interleukin-4

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01 juin 1994

publication

Mycoplasma arthritidis-derived superantigen induces proinflammatory monokine gene expression in the THP-1 human monocytic cell line

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01 déc. 1993

publication

Antigen-dependent stimulation by bone marrow-derived mast cells of MHC class II-restricted T cell hybridoma

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01 avr. 1993

publication

Anti-histone autoantibodies react specifically with the B cell surface

Lire plus

01 janv. 1993

publication

Characterization of anergy to the superantigen Staphylococcus enterotoxin B

Lire plus

01 janv. 1993

publication

Differential expression of T cell receptor variable beta genes on CD4+ and CD8+ T cells: influence by sex linked genes?

Lire plus

01 déc. 1992

publication

A stimulatory Mls-1 superantigen is destroyed by ultraviolet light while other Mtv-7 antigens remain intact. Significance for Mls-1 unresponsiveness

Lire plus

01 oct. 1992

publication

Regulation of T cell function by Mtv-7 gene products

Lire plus

01 oct. 1992

publication

Interleukin-2 may enhance or inhibit antibody production by B cells depending on intracellular cAMP concentrations

Lire plus

01 juin 1992

publication

In vivo presentation of Mls-1 antigen by T and B lymphocytes

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01 déc. 1991

publication

B cells control the aggregability of CD4 on T cells through continuous physical interactions

Lire plus

01 nov. 1991

publication

Induction of neonatal tolerance to the Mls-1a self-super-antigen. Time kinetics and MHC restriction

Lire plus

01 avr. 1991

publication

A characteristic Mls-1a response precedes Mls-1a anergy in vivo

Lire plus

01 avr. 1991

publication

Does interleukin-1 save B cells from paralysis? Studies with pre-B cells and antigen-reactive B cells

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15 févr. 1990

publication

Immunogenic Ia-binding peptides immobilize the Ia molecule and facilitate its aggregation on the B cell membrane. Control by the M1s-1 gene

Lire plus

15 févr. 1990

publication

Immunogenic peptides require an undisturbed phospholipid cell membrane environment and must be amphipathic to immobilize Ia on B cells

Lire plus

01 janv. 1989

publication

Release of allergens from Cladosporium conidia

Lire plus

15 nov. 1988

publication

Study of the epitope structure of purified Dac G I and Lol p I, the major allergens of Dactylis glomerata and Lolium perenne pollens, using monoclonal antibodies

Lire plus

01 mai 1988

publication

Demonstration of idiotypes expressed on basophil-bound IgE antibodies by using anti-idiotype-induced histamine release in grass pollen-allergic patients

Lire plus

01 mars 1987

publication

Biological effect of transferrin on mast cell mediator release during the passive cutaneous anaphylaxis reaction: a possible inhibition mechanism involving iron

Lire plus

01 mars 1985

publication

Production of a monoclonal antibody against a major allergen of Dactylis glomerata pollen (Dg1)

Lire plus

01 janv. 1985

publication

Purification and characterization of a major allergen from Dactylis glomerata pollen: the Ag Dg1

Lire plus

01 janv. 1985

publication

Induction of a passive cutaneous anaphylaxis inhibitory factor in mice

Lire plus

01 janv. 1984

publication

Presence of IL 1 activity in the supernatant of human monocytes challenged with purified allergenic constituents

Lire plus

01 mai 1983

publication

Inhibition of the passive cutaneous anaphylaxis reaction to Dactylis glomerata pollen allergens by a purified component of this pollen

Lire plus

01 janv. 1983

publication

Relationship between cytidine 5’diphosphocholine epitope density on ovalbumin and IgE antibody responses compared to other isotypes

Lire plus

01 nov. 1975

publication

Responses to drug therapy in ulcerative colitis. Evaluation by rectal biopsy and histopathological changes

Lire plus

Un petit guide pour l'utilisation de la recherche avancée :

Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.

PhD thesis defense Morgane Grand

Immunological memory to blood-stage malaria infection is controlled by the histamine releasing factor (HRF) of the parasite

The antimicrobial molecule trappin-2/elafin has anti-parasitic properties and is protective in vivo in a murine model of cerebral malaria

Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites

Risk factors associated with asthma, atopic dermatitis and rhinoconjunctivitis in a rural Senegalese cohort

P. berghei, a rodent malaria model to investigate host-parasite interactions central for malaria pathogenesis

Disruption of Parasite hmgb2 Gene Attenuates Plasmodium berghei ANKA Pathogenicity

Plasmodium berghei histamine-releasing factor favours liver-stage development via inhibition of IL-6 production and associates with a severe outcome of disease

Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis

Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

Impact of mosquito bites on asexual parasite density and gametocyte prevalence in asymptomatic chronic Plasmodium falciparum infections and correlation with IgE and IgG titers.

Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells

Duality and complexity of allergic type inflammatory mechanisms in determining the outcome of malaria disease

Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria

Downregulation of basophil-derived IL-4 and in vivo T(H)2 IgE responses by serotonin and other organic cation transporter 3 ligands

Anopheles stephensi saliva enhances progression of cerebral malaria in a murine model

Contribution of allergic inflammatory response to the pathogenesis of malaria disease

Human and mouse mast cells express and secrete the GPI-anchored isoform of CD160

Strain-transcendent immune response to recombinant Var2CSA DBL5-ε domain block P. falciparum adhesion to placenta-derived BeWo cells under flow conditions

Histamine H(3) receptor-mediated signaling protects mice from cerebral malaria

[Role of histamine and histamine receptors in the pathogenesis of malaria]

Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease

Total and functional parasite specific IgE responses in Plasmodium falciparum-infected patients exhibiting different clinical status

Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites

Comparison of the allergenic potency of spores and mycelium of Cladosporium

Anopheles mosquito bites activate cutaneous mast cells leading to a local inflammatory response and lymph node hyperplasia

Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects

Human serum IgE-mediated mast cell degranulation shows poor correlation to allergen-specific IgE content

[Immunological and non immunological mechanisms in urticaria]

Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo

Immunoregulatory properties of mast cell-derived exosomes

Capacity of mouse mast cells to prime T cells and to induce specific antibody responses in vivo

Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes

Nonspecific B and T cell-stimulatory activity mediated by mast cells is associated with exosomes

In vitro and in vivo immunostimulatory potential of bone marrow-derived mast cells on B- and T-lymphocyte activation

FcepsilonRI-mediated antigen endocytosis turns interferon-gamma-treated mouse mast cells from inefficient into potent antigen-presenting cells

Expression of functional major histocompatibility complex class II molecules on HMC-1 human mast cells

Specific antigen targeting to surface IgE and IgG on mouse bone marrow-derived mast cells enhances efficiency of antigen presentation

IL-4 mRNA transcription is induced in mouse bone marrow-derived mast cells through an MHC class II-dependent signaling pathway

Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation

Functional analysis of Mycoplasma arthritidis-derived mitogen interactions with class II molecules

Unravelling the mast cell dilemma: culprit or victim of its generosity?

Exogenous and endogenous antigens are differentially presented by mast cells to CD4+ T lymphocytes

Mouse bone marrow-derived mast cells and mast cell lines constitutively produce B cell growth and differentiation activities

Presentation of soluble antigens by mast cells: upregulation by interleukin-4 and granulocyte/macrophage colony-stimulating factor and downregulation by interferon-gamma

Modulation of Mycoplasma arthritidis-derived superantigen-induced cytokine gene expression by dexamethasone and interleukin-4

Mycoplasma arthritidis-derived superantigen induces proinflammatory monokine gene expression in the THP-1 human monocytic cell line

Antigen-dependent stimulation by bone marrow-derived mast cells of MHC class II-restricted T cell hybridoma

Anti-histone autoantibodies react specifically with the B cell surface

Characterization of anergy to the superantigen Staphylococcus enterotoxin B

Differential expression of T cell receptor variable beta genes on CD4+ and CD8+ T cells: influence by sex linked genes?

A stimulatory Mls-1 superantigen is destroyed by ultraviolet light while other Mtv-7 antigens remain intact. Significance for Mls-1 unresponsiveness

Regulation of T cell function by Mtv-7 gene products

Interleukin-2 may enhance or inhibit antibody production by B cells depending on intracellular cAMP concentrations

In vivo presentation of Mls-1 antigen by T and B lymphocytes

B cells control the aggregability of CD4 on T cells through continuous physical interactions

Induction of neonatal tolerance to the Mls-1a self-super-antigen. Time kinetics and MHC restriction

A characteristic Mls-1a response precedes Mls-1a anergy in vivo

Does interleukin-1 save B cells from paralysis? Studies with pre-B cells and antigen-reactive B cells

Immunogenic Ia-binding peptides immobilize the Ia molecule and facilitate its aggregation on the B cell membrane. Control by the M1s-1 gene

Immunogenic peptides require an undisturbed phospholipid cell membrane environment and must be amphipathic to immobilize Ia on B cells

Release of allergens from Cladosporium conidia

Study of the epitope structure of purified Dac G I and Lol p I, the major allergens of Dactylis glomerata and Lolium perenne pollens, using monoclonal antibodies

Demonstration of idiotypes expressed on basophil-bound IgE antibodies by using anti-idiotype-induced histamine release in grass pollen-allergic patients

Biological effect of transferrin on mast cell mediator release during the passive cutaneous anaphylaxis reaction: a possible inhibition mechanism involving iron

Production of a monoclonal antibody against a major allergen of Dactylis glomerata pollen (Dg1)

Purification and characterization of a major allergen from Dactylis glomerata pollen: the Ag Dg1

Induction of a passive cutaneous anaphylaxis inhibitory factor in mice

Presence of IL 1 activity in the supernatant of human monocytes challenged with purified allergenic constituents

Inhibition of the passive cutaneous anaphylaxis reaction to Dactylis glomerata pollen allergens by a purified component of this pollen

Relationship between cytidine 5’diphosphocholine epitope density on ovalbumin and IgE antibody responses compared to other isotypes

Responses to drug therapy in ulcerative colitis. Evaluation by rectal biopsy and histopathological changes