Ligne de temps

Nicholas Malmquist
Chef(fe) de Projet
02 Nov 2015
course

Scientific Ethics Workshop

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28 Jul 2015
project

Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)

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08 Jul 2015
project

Targeting epigenetic factors for new intervention strategies

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30 Jun 2015
publication

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

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11 May 2015
team

Biologie des interactions hôte-parasite

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24 Nov 2014
publication

Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans

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09 Jul 2014
publication

Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compounds

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29 Jun 2014
publication

Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria

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09 Feb 2014
publication

Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures

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07 Jan 2013
publication

Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites

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24 Sep 2012
publication

Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

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28 Jul 2009
publication

Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds

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19 Mar 2009
publication

Host cell entry by apicomplexa parasites requires actin polymerization in the host cell

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04 Jun 2008
publication

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum

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26 Feb 2008
publication

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

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29 Jan 2008
publication

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase

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28 Feb 2007
publication

Detergent-dependent kinetics of truncated Plasmodium falciparum dihydroorotate dehydrogenase

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09 Mar 2006
publication

Regulation of surface coat exchange by differentiating African trypanosomes

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28 Mar 2005
publication

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

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01 Aug 2003
publication

Dissociation of cGMP accumulation and relaxation in myometrial smooth muscle: effects of S-nitroso-N-acetylpenicillamine and 3-morpholinosyndonimine

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19 Aug 2002
publication

Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity

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01 Sep 2001
publication

NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP

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01 Jan 2001
publication

Secretion of a nucleoside diphosphate kinase (Nm23-H2) by cells from human breast, colon, pancreas and lung tumors

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01 Jan 2001
publication

Ellagic acid inhibits nucleoside diphosphate kinase-B activity

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01 Jan 2001
publication

Actions of S-nitroso N-acetyl penicillamine and 3-morpholinosydonimine may involve disparate signaling pathways in myometrial smooth muscle

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