Timeline

28 Jul 2015

project

Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)

08 Jul 2015

project

Targeting epigenetic factors for new intervention strategies

24 Nov 2014

publication

Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans

09 Jul 2014

publication

Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compounds

29 Jun 2014

publication

Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria

09 Feb 2014

publication

Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures

07 Jan 2013

publication

Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites

24 Sep 2012

publication

Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

28 Jul 2009

publication

Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds

19 Mar 2009

publication

Host cell entry by apicomplexa parasites requires actin polymerization in the host cell

04 Jun 2008

publication

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum

26 Feb 2008

publication

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

29 Jan 2008

publication

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase

28 Feb 2007

publication

Detergent-dependent kinetics of truncated Plasmodium falciparum dihydroorotate dehydrogenase

09 Mar 2006

publication

Regulation of surface coat exchange by differentiating African trypanosomes

28 Mar 2005

publication

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

01 Aug 2003

publication

Dissociation of cGMP accumulation and relaxation in myometrial smooth muscle: effects of S-nitroso-N-acetylpenicillamine and 3-morpholinosyndonimine

19 Aug 2002

publication

Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity

01 Sep 2001

publication

NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP

01 Jan 2001

publication

Secretion of a nucleoside diphosphate kinase (Nm23-H2) by cells from human breast, colon, pancreas and lung tumors

01 Jan 2001

publication

Ellagic acid inhibits nucleoside diphosphate kinase-B activity

01 Jan 2001

publication

A little guide for advanced search:

Timeline

Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)

Targeting epigenetic factors for new intervention strategies

Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans

Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compounds

Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria

Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures

Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites

Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds

Host cell entry by apicomplexa parasites requires actin polymerization in the host cell

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase

Detergent-dependent kinetics of truncated Plasmodium falciparum dihydroorotate dehydrogenase

Regulation of surface coat exchange by differentiating African trypanosomes

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

Dissociation of cGMP accumulation and relaxation in myometrial smooth muscle: effects of S-nitroso-N-acetylpenicillamine and 3-morpholinosyndonimine

Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity

NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP

Secretion of a nucleoside diphosphate kinase (Nm23-H2) by cells from human breast, colon, pancreas and lung tumors

Ellagic acid inhibits nucleoside diphosphate kinase-B activity

Actions of S-nitroso N-acetyl penicillamine and 3-morpholinosydonimine may involve disparate signaling pathways in myometrial smooth muscle