Protein secretion in bacteria is highly specific. Substrates secreted via the Type II secretion nanomachines are fully folded prior to secretion and are specifically recognized in their native state. In some cases, they even […]
Protein synthesis machinery of Trypanosomatid as a therapeutic target
Pathogenic protozoans of the trypanosomatid group still remain a major world health problem. Cycling between insect vectors and mammalian hosts, Trypanosoma cruzi is the causative agent of Chagas disease, while over 20 Leishmania species […]
Binding mode of promising antituberculosis clinical compounds to their bacterial target
New therapeutic strategies are needed to combat the pandemics and the spread of multidrug resistant form of tuberculosis. This collaborative project between our group and Institut Pasteur of Korea aims to decipher the molecular […]
Type IV pili and pseudopili: structure, dynamics, assembly and molecular function Type IV pili and pseudopili assembled by type 2 secretion systems (T2SS) are thin dynamic fibers that perform diverse functions, from adherence, motility, […]
Bacterial Transmembrane Signaling
Bacteria display several mechanisms to adapt to their host-environment and successfully colonise it. One important mechanism of adaptation concerns the regulation of gene expression in response to external signals such as the presence of […]
Docking method based on saturation transfer difference NMR data, and means for its implementation WO 2019/011987
Detailed information on drug-target interaction is a prerequisite in academic and industrial programs of drug dicovery and hit-to-lead optimization. We present a new approach that combines NMR and docking to characterise drug-target interactions at […]
2019Structure and function of minor pilins of type IV pili, Med. Microbiol. Immunol. 2019 Nov;.
2019Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches, J. Biomol. NMR 2019 Jul;73(6-7):293-303.
2019Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus., Structure. 2019 Apr 9. doi: 10.1016/j.str.2019.03.021..
2018Target engagement and binding mode of an anti-tuberculosis drug to its bacterial target deciphered in whole living cells by NMR., Biochemistry. 2019 Feb 12;58(6):526-533. doi: 10.1021/acs.biochem.8b00975. .
20171H, 15N and 13C resonance assignments and secondary structure of PulG, the major pseudopilin from Klebsiella oxytoca type 2 secretion system., Biomol NMR Assign. 2017 Mar 3. doi: 10.1007/s12104-017-9738-7. .
2017Structure of the calcium-dependent type 2 secretion pseudopilus, Nat Microbiol. 2017 Oct 9. doi: 10.1038/s41564-017-0041-2.
2016Structural basis of the signaling through a bacterial membrane receptor HasR deciphered by an integrative approach., Biochem J. 2016 May 13. pii: BCJ20160131.
2015A tribute to Cécile Wandersman, Res. Microbiol. 2015 Jun;166(5):393-8.
2015NMR structure and dynamics of Q4D059, a kinetoplastid-specific and conserved protein from Trypanosoma cruzi, J. Struct. Biol. 2015 Apr;190(1):11-20.
2014(1)H, (15)N and (13)C resonance assignments and secondary structure prediction of Q4D059, a conserved and kinetoplastid-specific hypothetical protein from Trypanosoma cruzi, Biomol NMR Assign 2015 Apr;9(1):161-3.
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