Structure Content

Extracellular vesicles (EVs), produced by eukaryotes, bacteria and archaea are increasingly recognized as important mediators of intercellular communication via transfer of a wide variety of molecular cargoes. Recently EVs of several intracellular pathogens have […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Bacteria exchange and recombine DNA to accelerate their evolution and adapt to new stress. Their evolvability is illustrated by the rapid emergence of multi resistant bacteria after the introduction of antibiotics. The most powerful […]

Désolé, cet article est seulement disponible en EN.

Présentation MITOBACT est une demande d’utilisation à des fins scientifiques de données et d’échantillons biologiques collectés auprès de participants de la cohorte COSIPOP. Quel est l’objectif  ? L’objectif est de décrire les modifications du […]

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Désolé, cet article est seulement disponible en EN.

Infectious diseases are a major public health problem, and identification of novel potential therapeutic candidates is mandatory in a context of growing antibiotic resistance. As classical infection biology approaches are nearly exhausted in their […]

Although  many clinically and ecologically relevant processes are known to be  performed by biofilm communities composed of strict or facultative anaerobic bacteria, biofilms were often studied in  aerobic conditions.  We use in vitro anaerobic culture systems […]

Biofilms are universal traits of bacteria defined as mixed species communities characterized by high cell density, reduced diffusion and heterogeneous structures. These characteristics induce behaviors and phenotype that are not observed in planktonic microorganisms […]

Clostridium difficile (CD), recently reclassified as Clostridioides difficile, a Gram-positive spore-forming anaerobic bacterium, has rapidly emerged as the leading cause of antibiotic-associated diarrheal disease in hospitals worldwide. The incidence and severity of CD infections […]

The variable spectrum of diseases caused by C. difficile (CD) is correlated for the severe forms to the level of toxins produced during host infection. This strengthened the idea that regulation of toxin synthesis […]

CRISPR-Cas loci are the adaptive immune system of archaea and bacteria. They can capture pieces of invading DNA and use this information to degrade target DNA through the action of RNA-guided nucleases. The consequences […]

    Our research focuses on the pathogenesis of Helicobacter pyloriby studying both bacterial virulence factors and the relation between H. pylori and its infected host. H. pylori colonizes the stomach of about half the […]

Our Unit investigates and characterises the molecular, genetic and cellular basis of the infection by Legionella. Legionella are environmental bacteria but some species like Legionella pneumophila or Legionella longbeachae are also opportunistic pathogens that […]

The capacity to rapidly and accurately identify virulent strains of C. difficile in order to prevent severe and fatal infections remains a major chal- lenge for clinicians and investigators. Also, the evolution of an […]

In collaboration with the swiss consortium InfectX (https://www.infectX.ch) we have previously performed high through-put microRNA screens to identify novel gene networks modulating the infection of host cells by Listeria. We are now : 1) […]

CRISPR loci and the associated Cas genes are the adaptive immune system of archeae and bacteria. They have the ability to capture pieces of DNA from viruses and other invading genetic elements [1], and […]

Clostridium difficile, a Gram-positive, anaerobic, spore-forming bacterium, is a major cause of nosocomial infections such as antibiotic-associated diarrhea. Spores are the vector of its transmission and persistence in the environment. Despite the importance of […]