Intragenic duplications of genetic material have important biological roles because of their consequences in terms of protein sequence and structure. We developed Swelfe to find internal repeats at three levels. Swelfe quickly identifies statistically significant internal repeats in DNA and amino acid sequences and in protein structures using dynamic programming. The associated web server also shows the relationships between repeats at each level and facilitates visualisation of the results.
Authors: Anne-Laure Abraham (now at INRA), Joël Pothier (UPMC), Eduardo Rocha.