Lien vers Pubmed [PMID] – 26628922
Epigenetics Chromatin 2015;8:52
In female mice, while the presence of two-active X-chromosomes characterises pluripotency, it is not tolerated in most other cellular contexts. In particular, in the trophoblastic lineage, impairment of paternal X (X(P)) inactivation results in placental defects.