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© Nicola Festuccia, Institut Pasteur
Mouse embryonic stem cells stained for Ki67 (red) and Esrrb (green)
Publication : Epigenetics & chromatin

A rapid passage through a two-active-X-chromosome state accompanies the switch of imprinted X-inactivation patterns in mouse trophoblast stem cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Epigenetics & chromatin - 01 Dec 2015

Prudhomme J, Dubois A, Navarro P, Arnaud D, Avner P, Morey C

Link to Pubmed [PMID] – 26628922

Epigenetics Chromatin 2015;8:52

In female mice, while the presence of two-active X-chromosomes characterises pluripotency, it is not tolerated in most other cellular contexts. In particular, in the trophoblastic lineage, impairment of paternal X (X(P)) inactivation results in placental defects.

https://www.ncbi.nlm.nih.gov/pubmed/26628922