Présentation
Our overall goal is to understand the cellular and molecular aspects of immune response to SARS-CoV-2
virus in terms of activation of over-reactive immunity and induction of immune protection. COVIMUNE is
designed to target the priority of “pathophysiology of the disease” through the following objectives
1. To develop a cellular model to study human-viral interactions on the adaptive immune response
2. To dissect of how antigen-presenting cells (APCs) polarize T cell responses leading to over-reactive
immunological reaction and/or protective memory T cells
3. To investigate the role of regulatory T cell (Treg) in regulating immune responses
4. To identify CD4+ T cell epitopes of SARS-CoV-2 presented by APCs and validation of these
epitopes in patients recovered from COVID-19
5. To explore underlying immune mechanisms predisposing patients with diabetes and cardiovascular
diseases to severe COVID-19
