Présentation
Knowledge concerning the interaction of SARS-CoV-2 with human and bat cells is sparse. We will use state-of-the-art RNA-sequencing analysis, original bioinformatics tools, loss-of-function approaches and mechanistic studies to identify and characterize coding and non-coding genes that restrict viral replication in human and bat cells. Taking advantage of some of these naturally occurring viral inhibitors may be an effective strategy in the development of novel drugs to treat the disease.
