Although competitive interactions between bacteria (bacterial interference), are likely to represent a key aspect of many infectious processes, the nature of these interactions within mixed biofilm communities is poorly understood. We use in vitro biofilm models to study adhesion or growth-related bacterial interferences within mixed communities. We identify molecules released by bacteria in mixed biofilm environments contributing to competitive or cooperative behaviors affecting population dynamics.
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• López-Igual, R., Bernal-Bayard, J., Rodríguez-Patón, A., Ghigo, J.M., and Didier Mazel.(2019). Engineering synthetic toxin-intein weapons as specific antimicrobials Nature Biotechnology in press.
• Létoffé, S., S. Chalabev, J. Dugay, F. Stressmann, B. Audrain, J.C. Portais, F. Letisse, and J.M. Ghigo. (2017). Biofilm microenvironment induces a widespread adaptive amino-acid fermentation pathway conferring strong fitness advantage in Escherichia coli. PLoS Genetics. May 19;13(5) doi: 10.1371.
• Rendueles, O., C. Beloin, P. Latour-Lambert, and J.M. Ghigo. (2014). A new biofilm-associated colicin targeting E. coli biofilm bacteria. The ISME Journal Jun. 8(6):1275-88. doi: 10.1038. .
Review on this topic
• Rendueles, O. and J.M. Ghigo. (2015). Mechanisms of competition in biofilm communities In Microbial Biofilms, second edition (M Ghannoum, M. Whiteley, M. Parsek, Eds.) ASM Press, Washington, DC, Microbiology Spectrum Jun. 3(3):0009-2014. doi: 10.1128/microbiolspec.MB-0009-2014.
• Audrain, B., S. Létoffé, and J.M. Ghigo. (2015). Airborne bacterial interactions: functions out of thin air? Frontiers in Microbiology Dec;6:1476. doi: 10.3389. (review).
• Rendueles, O. and J.M. Ghigo. (2012). Multi-species biofilms: How to avoid unfriendly neighbors. FEMS Microbiology Reviews
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