Thibault Lagache (PhD)
Permanent Researcher
- Institut Pasteur – Department of Cell Biology & Infection – BioImage Analysis Unit 25-28 rue du Docteur Roux, 75015 Paris – +33 (0)7 66 03 75 65
- thibault.lagache@pasteur.fr – thibault.lagache76@gmail.com
EDUCATION
- Université Paris Cité – HdR (2024) – Computer Sciences
- UPMC Paris 6 – PhD (2009) – Applied Mathematics (Highest honors)
- UPMC Paris 6 – Master 2 (2006) – Numerical Analysis (Highest honors)
- Ecole des Ponts ParisTech, France – Engineering Degree (2006) – Applied Mathematics & Computer Sciences
- Lycée Corneille, Rouen, France – Classes Préparatoires (2000-2002) – Mathematics & Physics (MPSI/MP*)
A.1 Professional experiences.
- Since 04/2024: Group Leader – Institut Pasteur, Department of Cell Biology and Infection, BioImage Analysis Unit – CNRS UMR 3691. Paris, France
- Since 07/2019: Permanent researcher – Institut Pasteur, Department of Cell Biology and Infection, BioImage Analysis Unit – CNRS UMR 3691. Paris, France
- 09/2016-06/2019 : Post-Doctoral Fellow – Columbia University, Department of Biological Sciences (P.I. Rafael Yuste) New-York, United States. Fellowships: Fondation Pour la Recherche Médicale (09-2016->09/2017, 30,000 €),Philippe Foundation (09-2016->09/2017, 7800 $ and 09-2017->09/2018 (renewal), 7500 $)
- 09/2011 – 03/2016 Post-Doctoral Researcher – Institut Pasteur, BioImage Analysis Unit (P.I. Jean-Christophe Olivo-Marin), CNRS UMR 3691. Paris, France Fellowships: Bourse Roux-Howard-Cantarini (09-2013->09/2015)
- 09/2010 – 09/2011 Research Assistant – Institut de la Vision, Genetics Physiologiy of Hearing Unit (P.I. Christine Petit) INSERM U587. Paris, France.
- 09/2009 – 09/2011 Temporary teacher and researcher ( A.T.E.R) – Université Paris Diderot, Laboratoire de Probabilités et Modèles Aléatoires CNRS 7599, Paris, France (Dir. Gilles Pagès).
- 09/2006 – 09/2009 Instructor -Université Paris Diderot. Paris, France.
- 09/2006 – 09/2009 PhD Student – Institut de Biologie de l’ENS (IBENS) – CNRS UMR8197, Inserm U1024. Team “Theoretical Modeling of Cellular Physiology” (P.I. David Holcman) Paris, France. PhD title: Stochastic modeling of early steps of viral infection Fellowships: Excellence Fellowship from Government of France-Ministry of Higher Education and Research
- 08/2004 – 08/2005 Quantitative Analyst – Crédit Agricole, Groupe de Recherche Opérationnel. Paris, France. Activity: Audit of stochastic models and their implementation for the pricing of exotic financial products
A.2 Grants
- ANR PRME (P.I) (2024-2028, 412,000 euros) – DECODE: Chasing functional ensembles in calcium imaging of Hydra’s neuronal activity to decode its behaviours’ repertoire
- ANR PRCI (P.I) in collaboration with Rafael Yuste (Columbia University) (2022-2025, 240,000 euros) – REBIRTH: Understanding the self-assembly of the nervous system of Hydra vulgaris
- ANR PRC (collaborator, P.I. Anne Brelot) (2021-2025, 53,000 euros) – GET-REDI: TarGETing CCR2 and CCR5 chemokine REceptors DImers: towards a better regulation of inflammation
A.3 Student Supervision
PhD Students
- Sarah Gaubi (2024-)
- Tristan Manneville (2024-)
- Philippe Aymard (2023-) (co-supervision with D. Holcman, ENS Paris)
- Raphaël Reme (2022-2025) (co-supervision with E. Angelini & A. Newson, Telecom Paris, J.-C. Olivo-Marin, Institut Pasteur)
- Samuel Kubler (2020-2023) (co-supervision with J.-C. Olivo-Marin, Institut Pasteur)
Master Students
- Sarah Gaubi, Sorbonne Université (2024)
- Aleksandr Kaminskii, Université Paris Saclay (2022)
- Corentin Vannier, INSA Lyon (2021)
- Victor Piriou, Sorbonne Université
- Catalina Gonzales, Summer Internship program, AMGEN
- Marina Lopez-Yunta, Sorbonne Université
- Quentin Marcou, Université de Paris
- Antoine Bardonnet, ENSIMAG Grenoble
- Laetitia Dufour, Sorbonne Université
- Anna Damato, Summer Internship program, Pasteur Foundation
- Thang Le, EURECOM Sophia-Antipolis.
A.4 Editorial board & Peer-reviewing
Associate Editor at Biological Imaging (Cambridge University Press) (2020-2024)
Peer-reviewing
- Scientific reports (2025-)
- Nature Computational Science (2023-)
- Cell Reports Methods (2023-)
- Biological Cybernetics (2022-)
- PLoS Computational Biology (2019-)
- Transaction in Image Processing (2017-)
- Biophysical Journal (2016-)
- Frontiers in Microbiology (2016-)
- Journal of Biological Physics (2016-)
- PLoS One (2015-)
A.4 Teaching
- 2023 : Advanced Course on Computational Neurosciences, Université Paris PSL
- 2015 : INSERM, France. Colocalization in Image Analysis, Icy Formation level 2
- 2014 : CNRS, France. Colocalization in Image Analysis, ANR Correlation in Image Analysis
- 2014 : Institut Pasteur Paris, France. Colocalization in Image Analysis, Molecular Biology of the Cell Course
- 2009-2011 : Université Paris Diderot. Paris, France. « A.T.E.R. » Algebra and Analysis (L1 level, 2009-2010), Statistics (L1 level, 2010-2011).
- 2006-2009 : Université Paris Diderot. Paris, France, « Moniteur » Probabilities and Scilab programming (L3 level)
C.1 Selected oral communications
- Imaging, modelling, and statistical advances in quantitative neuropathology workshop. Invited Talk. (The University of Oxford, Oxford, UK)
- Quantitative BioImaging Workshop on Spatial Statistics in Biological Imaging. Invited Talk “ Interrogating the organization of biological processes at different scales with spatial statistics” (Imperial College, Londres, UK) 2023
- Society for Neurosciences (SfN) Annual Meeting. Nanosymposium Talk “Modeling the nano-physiology of dendritic spines with electro-diffusion” (Washington DC, USA) 2017
- UPENN Math-bio seminar. Invited Talk “Spatial Statistics in Bioimage Analysis” (UPENN Philadelphia, USA) 2015
- ASCB Annual Meeting. Microsymposium Talk “Analyzing the spatial colocalization of synaptic molecules with SIM and spatial statistics” (San Diego, USA) 2015
- Quantitative BioImaging Conference. Contributed Talk “Analysis of the spatial organization of molecules with robust statistics” (Paris, France) 2015
- Workshop on Image-based Systems Biology, Invited Talk “Colocalization analysis of biomolecules” (Jena, Germany) 2015
- Workshop on spatial statistics Invited Talk “Analysis of the spatial organization of molecules with robust statistics” (Paris-Sup University, France) 2014
- Annual Meeting of the Club Exocytose-Endocytose Selected Talk “A statistical framework to analyze colocalization in bioimaging” (Pornichet, France) 2014
- Asilomar Conference- Selected Talk “Analysis of spatial clustering with robust statistics” (Pacific Grove, CA, U.S.A.) 2013
- SMAI bi-annual meeting- Selected Talk “Testing spatial clustering with fast and robust analytical statistics” (Seignosse le Penon, France) 2013
- ICIAM bi-annual meeting – Minisymposium “Modeling and Tracking Molecules: Signal Transduction, Aggregates” (Vancouver, Canada) 2011
- Gordon-Kenan Research Seminar (Physical Virology) – Selected Talk “Modeling the endosomal step of viral infection – Influenza as an example of enveloped viruses” (Ventura, U.S.A.) 2011
- Synthetic Biology in Pharma Conference – Invited Talk “Modeling the endosomal step of viral infection” (Cambridge, U.K.) 2010
- SIAM Conference on Dynamical Systems – Minisymposium “Molecular Diffusion and Transport in Cells” (Salt Lake City, U.S.A.) 2010
- SIAM Annual Meeting- Selected Talk “Quantifying intermittent transport in cell cytoplasm” (San Diego, U.S.A.) 2008