Samy Gobaa

In the human colon, mucus protects the underlying epithelium from pathogens. During infection, pathogens and resident microbiota compete for nutritional metabolites and therefore changes may alter the equilibrium in the colon ecosystem contributing to […]

Mechanical forces trigger many cellular functions and change the geometry and physical properties of a tissue. Very few studies look at the biomechanisms of invasion of microbes at tissue level. – In this project […]

Our objective is to generate inner ear organoids that can recapitulate in vitro the initial steps of the cochlear epithelium formation. In particular, we aim at generating these organoids in a micro-environment that allows […]

The use of new technological approaches including microfluidics and organ-on-chip strategies has permitted the design of advanced in vitro assays to address a variety of questions including in the study of human infections.  These […]

The intestine, and in particular the colon, comprising a mucus blanket, an epithelial monolayer and the lamina propria rich in immune cells, is constantly subjected to shear stress (flow) and peristaltic motion (stretching), both […]

The goal of this project is to develop a new organ-on-chip microfluidic device based on the actuation of thin hydrogel layers. Indeed, hydrogels possess interesting properties, compared to the commonly used perforated PDMS membranes. […]

What’s best to study humans and their infectious deseases than Human emulation system ? It’s now possible at Pasteur to develop real Organs-on-chips with cells from different sources, patient derived or cell line. At […]

The goals of this project are to build an external bioartificial liver, a liver-on-chip as well as a bioengineered liver. In the present project, bioconstruction of the liver will be performed by the assembly […]

Welcome to the club! Welcome to Microfluidics@Pasteur! Our goal is to serve as the major entry point to all the scientists on the campus (beginners and experts) interested in undertaking projects where microfluidics is involved. Our […]