Projets Projet En cours 8 Membres ERC-2017-COG_BinD – Mitotic Bookmarking, Stem Cells and early Development Pablo Navarro Gil (PI) The goal of this project is to deliver a new theoretical framework to understand how transcription factors (TFs) sustain cell identity during developmental processes. Recognised as key drivers of cell fate acquisition, TFs are […] Projet En cours 9 Membres Inheritance of the pluripotency network’s activity Pablo Navarro Gil (PI) The preservation of pluripotency throughout cell division – self-renewal -, is strictly dependent on the highly efficient action of the pluripotency gene regulatory network. However, how TFs cope with replication and mitosis, two major […]
Publications Télécharger 2024 Nicola Festuccia, Sandrine Vandormael-Pournin, Almira Chervova, Anna Geiselman, Francina Langa, Rémi-Xavier Coux, Inma Gonzalez, Guillaume Giraud Collet, Michel Cohen-Tannoudji, Pablo Navarro, Nr5a2 is dispensable for zygotic genome activation but essential for morula development, Science, 2024, 386 (6717), pp.eadg7325. ⟨10.1126/science.adg7325⟩. 2024 Rémi-Xavier Coux, Agnès Dubois, Almira Chervova, Nicola Festuccia, Inma Gonzalez, Sandrine Vandormael-Pournin, Michel Cohen-Tannoudji, Pablo Navarro, Molecular and epistatic interactions between pioneer transcription factors shape nucleosome dynamics and cell differentiation, 2024. 2024 Chervova A, Molliex A, Baymaz HI, Coux RX, Papadopoulou T, Mueller F, Hercul E, Fournier D, Dubois A, Gaiani N, Beli P, Festuccia N, Navarro P, Mitotic bookmarking redundancy by nuclear receptors in pluripotent cells., Nat Struct Mol Biol 2024 Jan; (): .