Clinical development of cancer vaccines
CyaA-based therapeutic cancer vaccines Based on our discovery that a bacterial protein, the adenylate cyclase (CyaA), binds to dendritic cells (DCs), we have developed a highly efficient vector capable of targeting a wide range […]
Tumor immunity and preclinical development of cancer vaccines
Human Papillomaviruses (HPV) are the major cause of human cervical cancer. We have developed a therapeutic tumor vaccine, the CyaA-E7 vaccine, that can induce specific responses against the HPV E7 oncoprotein and eliminate E7 […]
2018Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells., Nat Commun. 2018 Jun 8;9(1):2241.
2018Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling., Cancer Res. 2018 Jun 1;78(11):3014-3026.