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Private: PTR 403 – Generation and validation of innovative tools for 2D- and 3D-real time imaging of trypanosomatid parasites in their mammalian hosts
Thierry Lang (PI)
Trypanosomatidae are a widespread group of flagellated protozoa that cause highly disabling, often fatal, diseases and economic losses in endemic countries. Distinct Trypanosomatidae, transmitted by specific arthropod vectors, can cause human diseases: Trypanosoma (T) […]
Paola Minoprio (PI)
Combining bioinformatics and immunobiology towards the identification of Trypanosoma vivax specific markers. Despite closely related, South American and West African T. vivax are genetically distinct and these populations largely differ from those circulating in […]
Paola Minoprio (PI)
Towards the development of diagnostic tests for Chagas disease and post-treatment monitoring by the use of specific markers of the parasite Trypanosoma cruzi and prognostic biomarkers of chronic phase of infection. Current methods available […]
Paola Minoprio (PI)
Concerted effort to address rational drug design against Chagas disease Through a multidisciplinary approach that combine medicinal chemistry, structural bioinformatics, molecular docking and immunobiology of the infectious process, we identified two new inhibitors of […]
Paola Marcella Camargo Minoprio, Brazilian and French
Senior Associate Professor, Institut Pasteur, Paris, France
Head of the Laboratory Trypanosomatids Infectious Processes, where she has been working since 1984.
Ph.D. Immunology, 1989, University Paris 6, Paris, France; ‘Dr. 3ème Cycle’/Mestrado, 1985, Parasitology, University of Sao Paulo, Brazil; M.Sc., 1979, Parasitology, Universidade de Sao Paulo, Brazil and Institut Pasteur, Lille, France; Graduated in Biomedicine [B. Sc. (Hons)], 1978, UMC, Sao Paulo, Brazil.
Skilled in Business and Project Management (Institut pour le Développement économique et Technique, Paris, 2008), holds a University Diploma (MSc) in Innovation & Intellectual Property Strategies (Institut Européen Entreprise et Propriété Intellectuelle, Faculté d’Economie, University of Strasbourg, France, 2010).
Post-doctoral studies : 1992, DNAX Research Center for Molecular and Cellular Biology, Palo Alto, CA, U.S.A.; 1990, Fred Hutchinson Cancer Research Center, Seattle, WA, U.S.A.; Other studies trainings:1984, Basel Institute for Immunology, Switzerland; 1980-83, Laboratory of Immunology of Parasitic Infections, Department of Immunology, University of Sao Paulo, Brazil; 1979, Center of Immunology and Parasite Biology, Institut Pasteur Lille, France; 1978, Tropical Medicine Institute, University of Sao Paulo, Brazil.
Positions held: Institut Pasteur, Department of Infection and Epidemiology, Paris, France: From 2007, Senior Associate Professor; Department of Immunology, 1997-2007, Senior Associate Professor, Infectious Immunophysiopathology Unit, CNRS 1961, 1992-1996 Associate Professor, Experimental Parasitology and Biology of Host Parasite Interaction Units; 1989-1991 Associate Professor, Immunoparasitology Unit. 1986-1988, Assistant Professor (Tenure track), Fondation Roux, Immunoparasitology Unit, CNRS 1960. Institut Nationale de la Recherche Agronomique (INRA), Maisons Alfort, France : 1985-1986, Associate Professor, Ecole Nationale Vétérinaire de Maisons Alfort, Department of Immunogenetics, INSERM ; 1999-2012, Pierre et Marie Curie University, Paris 6, France, Chiefly responsible for Master Courses, University Lecturer. From 2005, Annual teaching at the École Nationale Supérieure des Mines de Paris.
Inter alia :
From 2015 – holds a “Franco Brazilian Chair” (catedra) Institut Pasteur/USP.
From 2009 – member of the Committe UPMC, Paris 6, for integration of Full-Professors ; 2004-2008 member of the Committee Pathogenesis and Applied Genomics, TDR, WHO, From 2004- , Expert European Community, 2003-2005, Coordinator of AMSUD/Pasteur Network and Coordinator American Pole, Réseau International Institut Pasteur (RIIP), 1992-97, Associate Professor (Health Ministry), FIOCRUZ, Department of Cellular and Molecular Biology, Rio de Janeiro, Brazil; 1980-1983, Lecturer in Biology, Instituto Unificado Objetivo, Sao Paulo, Brazil.
From 2001- 2005, She was commissioned to act as General Coordinator of the Pole Americas of the International Network of Pasteur Institutes (RIIP). Conducted and settled the affiliation of FIOCRUZ to RIIP. Negotiated and implemented several bilateral cooperation agreements (i.e. FIOCRUZ / Pasteur, FAPESP / Pasteur), more than 20 regional MERCOSUR courses, several projects in partnership for AMSUD / Pasteur network and organized bio-entrepreneurship forums in Brazil, Uruguay and Chile.
From 2014, She was commissioned to promote, establish end consolidate a strategic scientific partnership with University of Sao Paulo and FIOCRUZ aiming at the future implementation of the Institut Pasteur and RIIP in Brazil.
Her scientific approaches, mainly focusing on parasite mechanisms of escape and persistence in the host, basically aim at the development of therapeutic and / or immunizing molecules using parasitic mitogens and superantigens as targets. She pursues a multidisciplinary strategy that includes immunology, molecular and cell biology, protein-ligand interactions, medicinal chemistry, molecular dynamics and in silico screening.
Supervised several masters and doctoral theses, organized a number of symposia and courses, including those of Immunology sponsored by Yakult in Brazil, contributing to the implementation of human resources in the area. Scientific expert for various national and international agencies and scientific journals.
Author of numerous scientific publications, most as leading author, in the field of Immunopathology of infectious processes, mechanisms of parasite immune evasion, Immuno(chemo)therapy and approaches to vaccination. ). She holds a significant patent portfolio U.S., Europe, Brazil, China and India.
 Department of Infection and Epidemiology & Department of Parasitology, Institut Pasteur, 25 rue Du Dr Roux 75724, Paris, France
2015Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax, PLoS Negl Trop Dis 2015 Aug;9(8):e0003975.
2015Phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences, Parasit Vectors 2015;8:222.
2013In vivo imaging of trypanosomes for a better assessment of host-parasite relationships and drug efficacy, Parasitol. Int. 2014 Feb;63(1):260-8.
2013Combined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight Chagas’ disease, PLoS ONE 2013;8(4):e60955.
2013Non-invasive in vivo study of the Trypanosoma vivax infectious process consolidates the brain commitment in late infections, PLoS Negl Trop Dis 2013;7(1):e1976.
2011Genetic engineering of Trypanosoma (Dutonella) vivax and in vitro differentiation under axenic conditions, PLoS Negl Trop Dis 2011 Dec;5(12):e1461.
2011Drug discovery targeting amino acid racemases, Chem. Rev. 2011 Nov;111(11):6919-46.
2010Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. II. Immunobiological dysfunctions, PLoS Negl Trop Dis 2010;4(8).
2010Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters, PLoS Negl Trop Dis 2010;4(8):e792.
2010Intravenous immunoglobulin increases survival time in the acute phase of experimental Chagas disease, Parasite Immunol. 2010 Jun;32(6):464-9.
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