Timeline

Paola Minoprio

Head of Structure

01 Jan 2021

publication

Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient.

12 Sep 2015

project

T. vivax-Diag

12 Sep 2015

project

ChagasDiag

12 Aug 2015

publication

Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax

02 Jul 2015

project

Chagas

11 May 2015

team

Trypanosomatids Infectious Processes

12 Apr 2015

publication

Phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences

25 Jul 2013

publication

In vivo imaging of trypanosomes for a better assessment of host-parasite relationships and drug efficacy

16 Apr 2013

publication

Combined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight Chagas’ disease

03 Jan 2013

publication

Non-invasive in vivo study of the Trypanosoma vivax infectious process consolidates the brain commitment in late infections

27 Dec 2011

publication

Genetic engineering of Trypanosoma (Dutonella) vivax and in vitro differentiation under axenic conditions

13 Sep 2011

publication

Drug discovery targeting amino acid racemases

10 Aug 2010

publication

Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. II. Immunobiological dysfunctions

10 Aug 2010

publication

Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters

01 Jun 2010

publication

Intravenous immunoglobulin increases survival time in the acute phase of experimental Chagas disease

01 Dec 2009

publication

Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection

01 Dec 2009

publication

Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection

01 Jul 2009

publication

Proline racemases: insights into Trypanosoma cruzi peptides containing D-proline

13 Feb 2009

publication

Proline racemases are conserved mitogens: characterization of a Trypanosoma vivax proline racemase

12 Sep 2007

publication

Molecular and structural discrimination of proline racemase and hydroxyproline-2-epimerase from nosocomial and bacterial pathogens

30 Jan 2006

publication

Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase

01 Oct 2005

publication

Trypanosoma cruzi proline racemases are involved in parasite differentiation and infectivity

01 May 2003

publication

Biochemical characterization of proline racemases from the human protozoan parasite Trypanosoma cruzi and definition of putative protein signatures

01 Oct 2002

publication

Immunotherapy of Trypanosoma cruzi infections

01 Sep 2002

publication

Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin

01 May 2001

publication

Parasite polyclonal activators: new targets for vaccination approaches?

01 Feb 2001

publication

Significant association between the skewed natural antibody repertoire of Xid mice and resistance to Trypanosoma cruzi infection

01 Aug 2000

publication

A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase

01 Feb 2000

publication

Lymphocyte polyclonal activation: a pitfall for vaccine design against infectious agents

01 Feb 2000

publication

Changes in the cytokine profile of lupus-prone mice (NZB/NZW)F1 induced by Plasmodium chabaudi and their implications in the reversal of clinical symptoms

01 Dec 1999

publication

Theileria annulata in CD5(+) macrophages and B1 B cells

01 Aug 1999

publication

A Trypanosoma cruzi alkaline antigen induces polyclonal B-cell activation of normal murine spleen cells by T-cell-independent, BCR-directed stimulation

01 Mar 1999

publication

Partial protection of mice against Trypanosoma cruzi after immunizing with the TcY 72 antigenic preparation

01 Feb 1999

publication

X-linked immunodeficiency affects the outcome of Schistosoma mansoni infection in the murine model

01 Jun 1998

publication

A 24,000 MW Trypanosoma cruzi antigen is a B-cell activator

01 Feb 1997

publication

Evidence for a protective role of tumor necrosis factor in the acute phase of Trypanosoma cruzi infection in mice

01 Aug 1996

publication

V beta 6-bearing T cells are involved in resistance to Trypanosoma cruzi infection in XID mice

01 Jun 1996

publication

Murine acariasis. II. Immunological dysfunction and evidence for chronic activation of Th-2 lymphocytes

01 Mar 1996

publication

The influence of T cell subsets on Trypanosoma cruzi multiplication in different organs

01 Mar 1996

publication

Ig-isotype patterns of primary and secondary B cell responses to Plasmodium chabaudi chabaudi correlate with IFN-gamma and IL-4 cytokine production with CD45RB expression by CD4+ spleen cells

01 Feb 1996

publication

Intranasal inoculation of Bordetella bronchiseptica in mice induces long-lasting antibody and T-cell mediated immune responses

01 Jan 1996

publication

Chagas’ disease is attenuated in mice lacking gamma delta T cells

01 Aug 1995

publication

The relative impact of bacterial virulence and host genetic background on cytokine expression during Mycobacterium avium infection of mice

01 May 1995

publication

Defects in the regulation of anti-DNA antibody production in aged lupus-prone (NZB x NZW)F1 mice: analysis of T-cell lymphokine synthesis

01 Mar 1995

publication

In vivo evidence for a non-T cell origin of interleukin-5

01 Sep 1994

publication

Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection

16 Aug 1994

publication

Murine AIDS protects mice against experimental cerebral malaria: down-regulation by interleukin 10 of a T-helper type 1 CD4+ cell-mediated pathology

01 Jul 1994

publication

Role of interleukin-6 in the induction of protective T cells during mycobacterial infections in mice

01 Jul 1994

publication

Increase of B-lymphocyte number and activity during experimental murine schistosomiasis mansoni

01 Mar 1994

publication

Skewed V beta TCR repertoire of CD8+ T cells in murine Trypanosoma cruzi infection

01 Jan 1994

publication

Endogenous IL-10 and IFN-gamma production controls thymic cell proliferation in mice acutely infected by Trypanosoma cruzi

15 Oct 1993

publication

Xid-associated resistance to experimental Chagas’ disease is IFN-gamma dependent

01 May 1992

publication

CD5 B cells. Potential role in the (auto)immune responses to Trypanosoma cruzi infection

01 Jan 1992

publication

V-region-related and -unrelated immunosuppression accompanying infections

01 May 1991

publication

Xid immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas’ disease

01 Feb 1991

publication

Chagas’ disease: Trypanosoma cruzi vs. the host immune system

01 Feb 1991

publication

Is TNF alpha involved in early susceptibility of Trypanosoma cruzi-infected C3H/He mice?

01 Feb 1991

publication

Chagas’ disease: CD5 B-cell-dependent Th2 pathology?

01 Dec 1989

publication

Immunobiology of murine T. cruzi infection: the predominance of parasite-nonspecific responses and the activation of TCRI T cells

01 Nov 1989

publication

Further phenotypic characterization of target cells for bovine leukemia virus experimental infection in sheep

01 Jul 1989

publication

Susceptible mice present higher macrophage activation than resistant mice during infections with myotropic strains of Trypanosoma cruzi

01 Jun 1989

publication

Indiscriminate representation of VH-gene families in the murine B lymphocyte responses to Trypanosoma cruzi

01 Jan 1989

publication

Preferential expansion of Ly-1 B and CD4- CD8- T cells in the polyclonal lymphocyte responses to murine T. cruzi infection

01 Nov 1988

publication

Most B cells in acute Trypanosoma cruzi infection lack parasite specificity

01 Nov 1988

publication

Lymphocyte subpopulations and clonal repertoires participate in immune response to acute T. cruzi infection

01 Nov 1988

publication

Depletion of L3T4+ T lymphocytes during acute Trypanosoma cruzi infection abolish macrophage and B lymphocyte activation but not tissue inflammatory reaction

01 May 1988

publication

Parasitic load increases and myocardial inflammation decreases in Trypanosoma cruzi-infected mice after inactivation of helper T cells

15 Jul 1987

publication

Suppression of polyclonal antibody production in Trypanosoma cruzi-infected mice by treatment with anti-L3T4 antibodies

01 Dec 1986

publication

Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. I. Quantitation of both T- and B-cell responses

01 Dec 1986

publication

Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. II. Cytotoxic T lymphocytes

01 Jul 1986

publication

Persistence of polyclonal B cell activation with undetectable parasitemia in late stages of experimental Chagas’ disease

01 Jan 1980

publication

In vitro study of immunological events in human and experimental schistosomiasis: relationships between cytotoxic antibodies and circulating Schistosoma antigens

A little guide for advanced search:

Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient.

T. vivax-Diag

ChagasDiag

Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax

Chagas

Trypanosomatids Infectious Processes

Phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences

In vivo imaging of trypanosomes for a better assessment of host-parasite relationships and drug efficacy

Combined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight Chagas’ disease

Non-invasive in vivo study of the Trypanosoma vivax infectious process consolidates the brain commitment in late infections

Genetic engineering of Trypanosoma (Dutonella) vivax and in vitro differentiation under axenic conditions

Drug discovery targeting amino acid racemases

Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. II. Immunobiological dysfunctions

Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters

Intravenous immunoglobulin increases survival time in the acute phase of experimental Chagas disease

Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection

Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection

Proline racemases: insights into Trypanosoma cruzi peptides containing D-proline

Proline racemases are conserved mitogens: characterization of a Trypanosoma vivax proline racemase

Molecular and structural discrimination of proline racemase and hydroxyproline-2-epimerase from nosocomial and bacterial pathogens

Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase

Trypanosoma cruzi proline racemases are involved in parasite differentiation and infectivity

Biochemical characterization of proline racemases from the human protozoan parasite Trypanosoma cruzi and definition of putative protein signatures

Immunotherapy of Trypanosoma cruzi infections

Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin

Parasite polyclonal activators: new targets for vaccination approaches?

Significant association between the skewed natural antibody repertoire of Xid mice and resistance to Trypanosoma cruzi infection

A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase

Lymphocyte polyclonal activation: a pitfall for vaccine design against infectious agents

Changes in the cytokine profile of lupus-prone mice (NZB/NZW)F1 induced by Plasmodium chabaudi and their implications in the reversal of clinical symptoms

Theileria annulata in CD5(+) macrophages and B1 B cells

A Trypanosoma cruzi alkaline antigen induces polyclonal B-cell activation of normal murine spleen cells by T-cell-independent, BCR-directed stimulation

Partial protection of mice against Trypanosoma cruzi after immunizing with the TcY 72 antigenic preparation

X-linked immunodeficiency affects the outcome of Schistosoma mansoni infection in the murine model

A 24,000 MW Trypanosoma cruzi antigen is a B-cell activator

Evidence for a protective role of tumor necrosis factor in the acute phase of Trypanosoma cruzi infection in mice

V beta 6-bearing T cells are involved in resistance to Trypanosoma cruzi infection in XID mice

Murine acariasis. II. Immunological dysfunction and evidence for chronic activation of Th-2 lymphocytes

The influence of T cell subsets on Trypanosoma cruzi multiplication in different organs

Ig-isotype patterns of primary and secondary B cell responses to Plasmodium chabaudi chabaudi correlate with IFN-gamma and IL-4 cytokine production with CD45RB expression by CD4+ spleen cells

Intranasal inoculation of Bordetella bronchiseptica in mice induces long-lasting antibody and T-cell mediated immune responses

Chagas’ disease is attenuated in mice lacking gamma delta T cells

The relative impact of bacterial virulence and host genetic background on cytokine expression during Mycobacterium avium infection of mice

Defects in the regulation of anti-DNA antibody production in aged lupus-prone (NZB x NZW)F1 mice: analysis of T-cell lymphokine synthesis

In vivo evidence for a non-T cell origin of interleukin-5

Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection

Murine AIDS protects mice against experimental cerebral malaria: down-regulation by interleukin 10 of a T-helper type 1 CD4+ cell-mediated pathology

Role of interleukin-6 in the induction of protective T cells during mycobacterial infections in mice

Increase of B-lymphocyte number and activity during experimental murine schistosomiasis mansoni

Skewed V beta TCR repertoire of CD8+ T cells in murine Trypanosoma cruzi infection

Endogenous IL-10 and IFN-gamma production controls thymic cell proliferation in mice acutely infected by Trypanosoma cruzi

Xid-associated resistance to experimental Chagas’ disease is IFN-gamma dependent

CD5 B cells. Potential role in the (auto)immune responses to Trypanosoma cruzi infection

V-region-related and -unrelated immunosuppression accompanying infections

Xid immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas’ disease

Chagas’ disease: Trypanosoma cruzi vs. the host immune system

Is TNF alpha involved in early susceptibility of Trypanosoma cruzi-infected C3H/He mice?

Chagas’ disease: CD5 B-cell-dependent Th2 pathology?

Immunobiology of murine T. cruzi infection: the predominance of parasite-nonspecific responses and the activation of TCRI T cells

Further phenotypic characterization of target cells for bovine leukemia virus experimental infection in sheep

Susceptible mice present higher macrophage activation than resistant mice during infections with myotropic strains of Trypanosoma cruzi

Indiscriminate representation of VH-gene families in the murine B lymphocyte responses to Trypanosoma cruzi

Preferential expansion of Ly-1 B and CD4- CD8- T cells in the polyclonal lymphocyte responses to murine T. cruzi infection

Most B cells in acute Trypanosoma cruzi infection lack parasite specificity

Lymphocyte subpopulations and clonal repertoires participate in immune response to acute T. cruzi infection

Depletion of L3T4+ T lymphocytes during acute Trypanosoma cruzi infection abolish macrophage and B lymphocyte activation but not tissue inflammatory reaction

Parasitic load increases and myocardial inflammation decreases in Trypanosoma cruzi-infected mice after inactivation of helper T cells

Suppression of polyclonal antibody production in Trypanosoma cruzi-infected mice by treatment with anti-L3T4 antibodies

Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. I. Quantitation of both T- and B-cell responses

Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. II. Cytotoxic T lymphocytes

Persistence of polyclonal B cell activation with undetectable parasitemia in late stages of experimental Chagas’ disease

In vitro study of immunological events in human and experimental schistosomiasis: relationships between cytotoxic antibodies and circulating Schistosoma antigens