Nazarii Sabat, originating from Lviv (Ukraine) where he did his chemistry studies and obtained diploma from the National University of Lviv in 2012. Then he moved for his PhD to the group of Prof. Michal Hocek at IOCB & Charles University in Prague (Czech Republic). During his PhD, he worked on the synthesis of modified nucleobases for medicinal chemistry and chemical biology. In 2018, he moved to France for a postdoctoral stay, to work on the development of C-nucleosides as potent antiviral and antitumor agents in the group of Prof. Nadège Lubin-Germain at CY Cergy Paris University. In 2019, for his second postdoctoral stay, Nazarii joined the Institute of Chemistry of Natural Products (ICSN), CNRS (France) to work with Dr. Xavier Guinchard on enantioselective gold catalysis. During this time, he also participated in collaborative projects working with Dr. Olivier Berteau (INRAE) on biocatalysis and with Dr. Guillaume Vincent (ICMMO) on spiroindole natural product analogues. In March 2022, he joined the Institut Pasteur (Paris, France) to work on the controlled synthesis of antisense oligonucleotides in the group of Dr. Marcel Hollenstein collaborating with pharmaceutical company Roche (Switzerland).
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Publications
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2023Artificial nucleotide codons for enzymatic DNA synthesis, Chem. Commun., 2023,59, 14547-14550.
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2023Towards the controlled enzymatic synthesis of LNA containing oligonucleotides., Front Chem 2023 ; 11(): 1161462.
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2022Benzoyl and pivaloyl as efficient protecting groups for controlled enzymatic synthesis of DNA and XNA oligonucleotides, Asian J. Org. Chem. 2022, e202200384.
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2022Unbiased C3-Electrophilic Indoles: Triflic Acid Mediated C3-Regioselective Hydroarylation of N-H Indoles, Angew. Chem. Int. Ed. 2022, 61, e2022044.
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2022Enantioselective Au(I)-Catalyzed Multicomponent Annulation via Tethered Counterion-Directed Catalysis, ACS Catal. 2022, 12, 4046 - 4053.
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2022Synthesis, antiviral and antitumor activities investigations of a series of Ribavirin C-nucleoside analogue prodrugs, Bioorg. Chem. 2022, 122, 105723.
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2022Biochemical and XAS investigation of TsrM, a B12-dependent Radical SAM Enzyme Catalyzing Non-radical reaction, Chem. Eur. J. 2022, 28, e2022006.
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2020Gold-Catalyzed Enantioselective Functionalizations of Indoles, Org. Biomol. Chem. 2020, 18, 6006 – 6017.
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2020Gold-Catalyzed Spirocyclization Reactions of N-propargyl Tryptamines and Tryptophanes in Aqueous Media, Org. Lett. 2020, 22, 4344 – 4349.
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2019Synthesis and antitumor activities investigation of a C-nucleoside analogue of ribavirin, Eur. J. Med. Chem. 2020, 188, 112009.
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