Nathalie Aulner received her PhD in Molecular Biology from the University Paul Sabatier (Toulouse, France) after completing an engineer degree in Biochemistry and Biotechnology at the Institut National des Sciences Appliquées (Toulouse).
She joined the Institut Pasteur in 2009 to take charge of the High Content Analysis efforts in the PFID-Imagopole led by Pr. S. Shorte. Her areas of interest encompass the challenges of applying high content analysis to the study of infectious diseases, developing assays to achieve physiologically and clinically relevant conditions, live cell imaging and applying robust statistical methodologies. She is as well implicated in the facility training programs in microscopy and is the point of contact for all Health and Safety matters in the platform.
Before joining the Institut Pasteur, she worked for several years in the United States, including as an associate research scientist at the Columbia University Screening Center (New York) led by Dr J.E. Rothman and in the Functional Proteomic Project (joined ventures between the Memorial Sloan Kettering Cancer Center in New York and Amersham biosciences to set up a siRNA phenotypic screening facility).
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2024Staying on track – Keeping things running in a high-end scientific imaging core facility., J Microsc 2024 Jun; 294(3): 276-294.
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2024A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection., PLoS Biol 2024 Apr; 22(4): e3002259.
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2024An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus., Vet Res 2024 Mar; 55(1): 32.
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2022A Role for Taok2 in Listeria monocytogenes Vacuolar Escape., J Infect Dis 2022 Mar; 225(6): 1005-1010.
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2021LocalZProjector and DeProj: a toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images., BMC Biol 2021 Jul; 19(1): 136.
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2021Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols., Front Immunol 2021 ; 12(): 685768.
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2020Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response., Cell Rep 2020 Feb; 30(6): 1870-1882.e4.
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2020Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols., Front Immunol 2020 ; 11(): 569331.
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2019Author Correction: Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening., Sci Rep 2019 Jul; 9(1): 10148.
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2019Next-Generation Phenotypic Screening in Early Drug Discovery for Infectious Diseases, Trends Parasitol. 2019 Jul;35(7):559-570.
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