INCEPTION – INstitut Convergences pour l’étude de l’Émergence des Pathologies au Travers des Individus et des populatiONs et des
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Protein secretion in bacteria is highly specific. Substrates secreted via the Type II secretion nanomachines are fully folded prior to secretion and are specifically recognized in their native state. In some cases, they even […]
ViBrANT (Viral and Bacterial Adhesin Network Training)
The Innovative Training Network ViBrANT (Viral and Bacterial Adhesin Network Training) brings together world-leading European scientists to train 15 graduate students (early stage researchers) in interdisciplinary research into viral and bacterial adhesins. ViBrANT is […]
ARIA for hybrid structure determination on the cloud
Protein structure determination is crucial for understanding protein function, as it paves the way to the discovery of new drugs and of new approaches to control pathological biological processes. The recent advances in structural […]
AEGIS (Accelerated Early staGe drug dIScovery)
AEGIS is a Marie Skłodowska -Curie Innovative Training Network (ITN) for early stage researchers (ESR) funded by the European Commission under the H2020 Programme the EU framework programme for research and innovation. The principal […]
Binding mode of promising antituberculosis clinical compounds to their bacterial target
New therapeutic strategies are needed to combat the pandemics and the spread of multidrug resistant form of tuberculosis. This collaborative project between our group and Institut Pasteur of Korea aims to decipher the molecular […]
Type IV pili and pseudopili: structure, dynamics, assembly and molecular function Type IV pili and pseudopili assembled by type 2 secretion systems (T2SS) are thin dynamic fibers that perform diverse functions, from adherence, motility, […]
A Bayesian Framework for Cellular Structural Biology Objective : “The functioning of a single cell or organism is governed by the laws of chemistry and physics. The bridge from biology to chemistry and physics […]
About Bip:Bip The project Bip:Bip promotes an integrated use of known and modelled three-dimensional structures of proteins as an aid in complete genome annotation. The architectural organization of biological macromolecules is essential for the […]
Centre for the Analysis of Complex Systems in Complex Environments About CACSICE Cells function through transient interactions of macromolecular complexes. Understanding fully the dynamic processes of life at the molecular level requies understanding the […]
ARIA (Ambiguous Restraints for Iterative Assignment)
Our computer program ARIA (Ambiguous Restraints for Iterative Assignment) is a software for automated NOE assignment and NMR structure calculation. It speeds up and automatizes the assignment process through the use of an iterative […]
Docking method based on saturation transfer difference NMR data, and means for its implementation WO 2019/011987
Detailed information on drug-target interaction is a prerequisite in academic and industrial programs of drug dicovery and hit-to-lead optimization. We present a new approach that combines NMR and docking to characterise drug-target interactions at […]
2019Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches, J. Biomol. NMR 2019 Jul;73(6-7):293-303.
2019Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus., Structure. 2019 Apr 9. doi: 10.1016/j.str.2019.03.021..
2019Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling, Structure 27 (2019) 175-188.
2018Target engagement and binding mode of an anti-tuberculosis drug to its bacterial target deciphered in whole living cells by NMR., Biochemistry. 2019 Feb 12;58(6):526-533. doi: 10.1021/acs.biochem.8b00975. .
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2017Structure of the calcium-dependent type 2 secretion pseudopilus, Nat Microbiol 2017 Dec;2(12):1686-1695.
2016Structure determination of helical filaments by solid-state NMR spectroscopy, Proc. Natl. Acad. Sci. U.S.A. 2016 Jan;113(3):E272-81.
2015Neisseria meningitidis Type IV Pili Composed of Sequence Invariable Pilins Are Masked by Multisite Glycosylation, PLoS Pathog. 2015 Sep;11(9):e1005162.
2015Biogenesis and structure of a type VI secretion membrane core complex, Nature 2015 Jul;523(7562):555-60.
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