Energir: Comprendre les mécanismes moléculaires d’acquisition du fer chez les bactéries à Gram-négatif, par une approche intégrative
Les bactéries à Gram négatif sont entourées d’une enveloppe composée de deux membranes (les membranes dites externe et interne) séparées par l’espace périplasmique. Cette enveloppe contient des machines macromoléculaires qui assurent et régulent les […]
Protein secretion in bacteria is highly specific. Substrates secreted via the Type II secretion nanomachines are fully folded prior to secretion and are specifically recognized in their native state. In some cases, they even […]
ViBrANT (Viral and Bacterial Adhesin Network Training)
The Innovative Training Network ViBrANT (Viral and Bacterial Adhesin Network Training) brings together world-leading European scientists to train 15 graduate students (early stage researchers) in interdisciplinary research into viral and bacterial adhesins. ViBrANT is […]
ARIA for hybrid structure determination on the cloud
Protein structure determination is crucial for understanding protein function, as it paves the way to the discovery of new drugs and of new approaches to control pathological biological processes. The recent advances in structural […]
AEGIS (Accelerated Early staGe drug dIScovery)
AEGIS is a Marie Skłodowska -Curie Innovative Training Network (ITN) for early stage researchers (ESR) funded by the European Commission under the H2020 Programme the EU framework programme for research and innovation. The principal […]
Binding mode of promising antituberculosis clinical compounds to their bacterial target
New therapeutic strategies are needed to combat the pandemics and the spread of multidrug resistant form of tuberculosis. This collaborative project between our group and Institut Pasteur of Korea aims to decipher the molecular […]
Type IV pili and pseudopili: structure, dynamics, assembly and molecular function Type IV pili and pseudopili assembled by type 2 secretion systems (T2SS) are thin dynamic fibers that perform diverse functions, from adherence, motility, […]
A Bayesian Framework for Cellular Structural Biology Objective : “The functioning of a single cell or organism is governed by the laws of chemistry and physics. The bridge from biology to chemistry and physics […]
About Bip:Bip The project Bip:Bip promotes an integrated use of known and modelled three-dimensional structures of proteins as an aid in complete genome annotation. The architectural organization of biological macromolecules is essential for the […]
Centre for the Analysis of Complex Systems in Complex Environments About CACSICE Cells function through transient interactions of macromolecular complexes. Understanding fully the dynamic processes of life at the molecular level requies understanding the […]
ARIA (Ambiguous Restraints for Iterative Assignment)
Our computer program ARIA (Ambiguous Restraints for Iterative Assignment) is a software for automated NOE assignment and NMR structure calculation. It speeds up and automatizes the assignment process through the use of an iterative […]
ARIAweb: a server for automated NMR structure calculation
The ARIAweb server provides access to the main ARIA software functionalities (NMR data conversion and structure calculation). In addition, structure calculation results can be easily visualised, with a dedicated molecular viewer and graphical displays […]
Docking method based on saturation transfer difference NMR data, and means for its implementation WO 2019/011987
Detailed information on drug-target interaction is a prerequisite in academic and industrial programs of drug dicovery and hit-to-lead optimization. We present a new approach that combines NMR and docking to characterise drug-target interactions at […]
2023Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system., Structure 2023 Feb; 31(2): 152-165.e7.
2022Building Protein Atomic Models from Cryo-EM Density Maps and Residue Co-Evolution., Biomolecules 2022 Sep; 12(9): .
2022Secondary structure and 1H, 15 N & 13C resonance assignments of the periplasmic domain of OutG, major pseudopilin from Dickeya dadantii type II secretion system., Biomol NMR Assign 2022 Apr; (): .
2022Bat coronaviruses related to SARS-CoV-2 and infectious for human cells, Nature, 2022, 604 (7905), pp.330-336. ⟨10.1038/s41586-022-04532-4⟩.
2021InDeep: 3D fully convolutional neural networks to assist in silico drug design on protein-protein interactions., Bioinformatics 2021 Dec; (): .
20211 H, 15 N and 13 C resonance assignments of the C-terminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system, Biomol NMR Assign . 2021 Oct;15(2):455-459. .
2021Computational and biochemical analysis of type IV pilus dynamics and stability., Structure 2021 Dec; 29(12): 1397-1409.e6.
2021Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens., Diagnostics (Basel) 2021 Jul; 11(7): .
2021The iPPI-DB initiative: A Community-centered database of Protein-Protein Interaction modulators., Bioinformatics 2021 Jan; (): .
2019Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches, J. Biomol. NMR 2019 Jul;73(6-7):293-303.
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