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Education
2009-2012 PhD in Biochemistry – Université Pierre et Marie Curie, Parie, France 2007-2009 Master in Biochemistry – Université Pierre et Marie Curie, Parie, France
Research activities
Jan 2018-present Post-doctoral fellow – Institut Pasteur, Paris
Unité Récepteurs-Canaux led by Dr Pierre-Jean Corringer Structure-function of human nicotinic receptors
June 2013-Dec 2017 Post-doctoral fellow – Institute of Structural and Molecular Biology, Birkbeck College, London UK Prof. Gabriel Waksman’ Unit Characterization of the dot/icm secretion system of l. pneumophila.
Oct 2008- March 2013 Master 2 and PhD – Institut Pasteur, Paris, France /Université Paris IV (UPMC) – ED387 Unité Récepteurs-Canaux led by Dr Pierre-Jean Corringer Study of the allosteric transitions of channel-receptors
Awards and funding
2018-2020: Fondation ARC individual fellowship
2019: Qualification for « Maitre de Conférence » positions
2009-2012: PhD fellowship from the « Ministère de l’Enseignement Supérieur et de la Recherche »
Publications
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2021Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors., Cell Mol Life Sci 2021 Feb; 78(3): 1051-1064.
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2021Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients., Prog Neurobiol 2021 02; 197(): 101898.
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2018X-ray crystal structures of the type IVb secretion system DotB ATPases., Protein Sci. 2018 08; 27(8): 1464-1475.
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2017The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery, Sci Rep 2017 Aug;7(1):9450.
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2016Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels, Neuron 2016 05;90(3):452-70.
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2016Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus), Toxicon 2016 Jun;116:63-71.
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2015Secretion systems in Gram-negative bacteria: structural and mechanistic insights, Nat. Rev. Microbiol. 2015 Jun;13(6):343-59.
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2013Intermediate closed state for glycine receptor function revealed by cysteine cross-linking, Proc. Natl. Acad. Sci. U.S.A. 2013 Oct;110(42):17113-8.
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2013Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC, J. Med. Chem. 2013 Jun;56(11):4619-30.
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2012Structure and pharmacology of pentameric receptor channels: from bacteria to brain, Structure 2012 Jun;20(6):941-56.
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