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© Marie Prévost, Institut Pasteur
Image of a portion of a Xenopus oocyte expressing a channel receptor.

About

I am a postdoctoral researcher focusing on the understanding of the structure-function relationships of the human nicotinic receptors, and their role psychiatric and neurological diseases. I was trained during my PhD at the Institut Pasteur in electrophysiology and protein biochemistry, on a bacterial homologue of nicotinic receptors. My work allowed the identification of a new conformation of those receptors, using mutagenesis and electrophysiology coupled to structural biology. I then did a post-doctoral training in London, where I acquired an expertise in structural biology techniques to study the secretion system of the pathogenic bacteria Legionella pneumophila.

I joined the Channel-receptors team to work on human nicotinic receptors, focusing on the α5 and α7 containing subtypes. α5-receptors are involved in nicotine addiction and lung cancer while the α7 subtypes play fundamental roles in psychiatric disorders such as schizophrenia or Alzheimer’s disease. I combine biochemistry, X-ray crystallography, cryo-electron microscopy, biophysics and functional assays to elucidate their mechanisms of action in the human brain.

CV

Education

2009-2012 PhD in Biochemistry – Université Pierre et Marie Curie, Parie, France 2007-2009 Master in Biochemistry – Université Pierre et Marie Curie, Parie, France

Research activities

Jan 2018-present Post-doctoral fellow – Institut Pasteur, Paris
Unité Récepteurs-Canaux led by Dr Pierre-Jean Corringer Structure-function of human nicotinic receptors

June 2013-Dec 2017 Post-doctoral fellow – Institute of Structural and Molecular Biology, Birkbeck College, London UK Prof. Gabriel Waksman’ Unit Characterization of the dot/icm secretion system of l. pneumophila.

Oct 2008- March 2013 Master 2 and PhD – Institut Pasteur, Paris, France /Université Paris IV (UPMC) – ED387 Unité Récepteurs-Canaux led by Dr Pierre-Jean Corringer Study of the allosteric transitions of channel-receptors

Awards and funding

2018-2020: Fondation ARC individual fellowship
2019: Qualification for « Maitre de Conférence » positions
2009-2012: PhD fellowship from the « Ministère de l’Enseignement Supérieur et de la Recherche »

Publications

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