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© Marie Prévost, Institut Pasteur
Image of a portion of a Xenopus oocyte expressing a channel receptor.
Member: Permanent Researcher

Marie Prevost

• Channel Receptors

About

I am a permanent researcher focusing on the understanding of the structure-function relationships of the human nicotinic receptors, and their role psychiatric and neurological diseases.

My work explores the α5 and α7 containing nicotinic receptors subtypes. α5-receptors are involved in nicotine addiction and lung cancer while the α7 subtypes play fundamental roles in psychiatric disorders such as schizophrenia or Alzheimer’s disease. I combine biochemistry, X-ray crystallography, cryo-electron microscopy, biophysics and functional assays to elucidate their mechanisms of action in the human brain.

 

CV

Education

2009-2012 PhD in Biochemistry – Université Pierre et Marie Curie, Parie, France 2007-2009 Master in Biochemistry – Université Pierre et Marie Curie, Parie, France

Research activities
Oct 2023-present: Permanent Researcher (CRCN) | CNRS UMR 3571, Institut Pasteur, Paris
Integrative structural biology of human nicotinic receptors and their partners
Jan 2018- Aug 2023: Post-doctoral fellow | CNRS UMR 3571, Institut Pasteur, Paris

Structure-function of human nicotinic receptors (Supervisor Dr Pierre-Jean Corringer)

June 2013-Dec 2017: Post-doctoral fellow | UCL-Birkbeck College, London UK
Characterization of the secretion system of l. pneumophila. (Supervisor Prof. Gabriel Waksman
Sept 2009- March 2013: PhD |Institut Pasteur, Paris, CNRS UMR 3571 – ED387
Study of the allosteric transitions of channel-receptors (Supervisor Dr Pierre-Jean Corringer)
Awards and funding

2024-2026: ANR JCJC NicoContact

2018-2020: Fondation ARC individual fellowship
2019: Qualification for « Maitre de Conférence » positions
2009-2012: PhD fellowship from the « Ministère de l’Enseignement Supérieur et de la Recherche »

Publications

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