Bacteriophage gene expression by RNA-Seq
Analyses of RNA-Seq data from two related virulent bacteriophages, PAK_P3 and PAK_P4 infecting the bacterium Pseudomonas aeruginosa.
Molecular characterization of therapeutic bacteriophages
Bacteriophages infecting pathogenic bacteria, which have been studied for their in vivo activities and defined as valuable for therapeutic application, are in this project, subject to molecular studies ranging from bacterial receptor identification to […]
Treatment of pulmonary infections
Pulmonary infections are a leading cause of death worldwide and infections caused by antibiotic-resistant bacteria are steadily increasing. We study how virulent bacteriophages can be used to treat bacterial lung infections. We develop infectious […]
Virulents bacteriophages and microbial ecosystems
Digestive tract of mammals is one of the most complex microbial ecosystems subject to both external and internal factors, through food consumption and interactions with intestinal cells. We are developing and using several experimental […]
De novo assembly for integration into MicroScope/MaGe platform
To perform the assembly of a bacterial genome from Illumina sequencing in order to submit it to the MicroScope/MaGe platform of Genoscope.
16S rDNA data analysis
To perform assignment of 16S sequences to bacterial genera and statistical analysis of variations of bacterial populations collected from mice feces
2019Phage Therapy of Pneumonia Is Not Associated with an Overstimulation of the Inflammatory Response Compared to Antibiotic Treatment in Mice, Antimicrob. Agents Chemother. 2019 Aug;63(8).
2019The Battle Within: Interactions of Bacteriophages and Bacteria in the Gastrointestinal Tract, Cell Host Microbe 2019 02;25(2):210-218.
2018Centennial celebration of the bacteriophage research, Res. Microbiol. 2018 11;169(9):479-480.
2018“I will survive”: A tale of bacteriophage-bacteria coevolution in the gut, Gut Microbes 2019;10(1):92-99.
2018The Diversity of Bacterial Lifestyles Hampers Bacteriophage Tenacity, Viruses 2018 06;10(6).
2018Design of a Broad-Range Bacteriophage Cocktail That Reduces Pseudomonas aeruginosa Biofilms and Treats Acute Infections in Two Animal Models, Antimicrob. Agents Chemother. 2018 Jun;62(6).
2017The Gut Microbiota Facilitates Drifts in the Genetic Diversity and Infectivity of Bacterial Viruses, Cell Host Microbe 2017 Nov;.
2017Synergy between the Host Immune System and Bacteriophage Is Essential for Successful Phage Therapy against an Acute Respiratory Pathogen, Cell Host Microbe 2017 Jul;22(1):38-47.
2017The Lysis of Pathogenic Escherichia coli by Bacteriophages Releases Less Endotoxin Than by β-Lactams, Clin. Infect. Dis. 2017 Jun;64(11):1582-1588.
2017Comparative transcriptomics analyses reveal the conservation of an ancestral infectious strategy in two bacteriophage genera, ISME J 2017 May;.
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