Think tank: Cancer
The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
Advanced Immunization Technologies (ADITEC)
We are member of the ADITEC Consortium, a collaborative research programme that aims to accelerate the development of novel and powerful immunisation technologies for the next generation of human vaccines. Scientists from 13 countries […]
Clinical development of cancer vaccines
CyaA-based therapeutic cancer vaccines Based on our discovery that a bacterial protein, the adenylate cyclase (CyaA), binds to dendritic cells (DCs), we have developed a highly efficient vector capable of targeting a wide range […]
Therapeutic potential of mycolactone and synthetic surrogates
Whether released by bacteria infecting the skin or injected via the subcutaneous route, mycolactone was found to diffuse into the leukocytes of peripheral blood and lymphoid organs. With this distribution profile, the unique effects […]
Tumor immunity and preclinical development of cancer vaccines
Human Papillomaviruses (HPV) are the major cause of human cervical cancer. We have developed a therapeutic tumor vaccine, the CyaA-E7 vaccine, that can induce specific responses against the HPV E7 oncoprotein and eliminate E7 […]
2023Sec61 blockade therapy overrides resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma., Front Oncol 2023 ; 13(): 1110916.
2022The Sec61 translocon is a therapeutic vulnerability in multiple myeloma., EMBO Mol Med 2022 03; 14(3): e14740.
2018Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells., Nat Commun. 2018 Jun 8;9(1):2241.
2018Tumor-Derived TGFβ Alters the Ability of Plasmacytoid Dendritic Cells to Respond to Innate Immune Signaling., Cancer Res. 2018 Jun 1;78(11):3014-3026.
2016B cells promote tumor progression in a mouse model of HPV-mediated cervical cancer, Int. J. Cancer 2016 Sep;139(6):1358-71.
2014Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses, J. Immunol. 2014 Aug;193(4):1787-98.
2012Pivotal role of plasmacytoid dendritic cells in inflammation and NK-cell responses after TLR9 triggering in mice, Blood 2012 Jul;120(1):90-9.
2008Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation, Blood 2008 Nov;112(9):3713-22.
2008Dynamics of immune cell recruitment during West Nile encephalitis and identification of a new CD19+B220-BST-2+ leukocyte population, J. Immunol. 2008 May;180(10):6760-7.
2006Purification of splenic dendritic cells induces maturation and capacity to stimulate Th1 response in vivo, Int. Immunol. 2006 Mar;18(3):445-52.
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