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Projets
CV
Marie-Elisabeth Bougnoux, obtained both her MD (1985), and her PhD (1999) at University Paris-Descartes Medical School where she is currently Associate-Professor of Parasitology-Mycology and Head of the Mycology-Parasitology laboratory of Necker Hospital, Paris (Fr.), a major referral center for immunocompromised patients, both adults and children. She is member of the Research Group “Unité Biologie et Pathogénicité Fongiques” since 2000. ME Bougnoux has focused her research on the biological and genetics/genomics aspects of Candida albicans. Specifically, she tries to decipher the complex relationships that C. albicans establishes with human hosts particularly when it switches from a commensal to a pathogen state causing severe infections with a high mortality rate. By combining her findings with detailed epidemiological and clinical observations in patients she aims to discover new therapeutic avenues and significantly change candidiasis outcome.
Publications
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2019Within-Host Genomic Diversity of Candida albicans in Healthy Carriers, Sci Rep 2019 Feb;9(1):2563.
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2018Clinical Impact of Antifungal Susceptibility, Biofilm Formation and Mannoside Expression of Yeasts on the Outcome of Invasive Candidiasis in ICU: An Ancillary Study on the Prospective AmarCAND2 Cohort, Front Microbiol 2018;9:2907.
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2018Generating genomic platforms to study Candida albicans pathogenesis, Nucleic Acids Res. 2018 Aug;46(14):6935-6949.
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2018Combined bacterial and fungal intestinal microbiota analyses: Impact of storage conditions and DNA extraction protocols, PLoS ONE 2018;13(8):e0201174.
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2018Systematic gene overexpression in Candida albicans identifies a regulator of early adaptation to the mammalian gut, Cell. Microbiol. 2018 Jul;:e12890.
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2018Gene flow contributes to diversification of the major fungal pathogen Candida albicans, Nat Commun 2018 Jun;9(1):2253.
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2017The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity, Mucosal Immunol 2017 Feb;.
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2016Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the Candida albicans Diploid Genome, MBio 2016 Oct;7(5).
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2016Prospective Evaluation of Serum β-Glucan Testing in Patients With Probable or Proven Fungal Diseases, Open Forum Infect Dis 2016 Sep;3(3):ofw128.
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2016Comparison of E,E-Farnesol Secretion and the Clinical Characteristics of Candida albicans Bloodstream Isolates from Different Multilocus Sequence Typing Clades, PLoS ONE 2016;11(2):e0148400.
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