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CV
Marie-Elisabeth Bougnoux, obtained both her MD (1985), and her PhD (1999) at University Paris-Descartes Medical School where she is currently Associate-Professor of Parasitology-Mycology and Head of the Mycology-Parasitology laboratory of Necker Hospital, Paris (Fr.), a major referral center for immunocompromised patients, both adults and children. She is member of the Research Group “Unité Biologie et Pathogénicité Fongiques” since 2000. ME Bougnoux has focused her research on the biological and genetics/genomics aspects of Candida albicans. Specifically, she tries to decipher the complex relationships that C. albicans establishes with human hosts particularly when it switches from a commensal to a pathogen state causing severe infections with a high mortality rate. By combining her findings with detailed epidemiological and clinical observations in patients she aims to discover new therapeutic avenues and significantly change candidiasis outcome.
Publications
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2020A conserved regulator controls asexual sporulation in the fungal pathogen Candida albicans., Nat Commun 2020 12; 11(1): 6224.
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2020The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives., FEMS Microbiol Rev 2020 Nov; (): .
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2019Within-Host Genomic Diversity of Candida albicans in Healthy Carriers, Sci Rep 2019 Feb;9(1):2563.
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2018Clinical Impact of Antifungal Susceptibility, Biofilm Formation and Mannoside Expression of Yeasts on the Outcome of Invasive Candidiasis in ICU: An Ancillary Study on the Prospective AmarCAND2 Cohort, Front Microbiol 2018;9:2907.
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2018Generating genomic platforms to study Candida albicans pathogenesis, Nucleic Acids Res. 2018 08;46(14):6935-6949.
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2018Combined bacterial and fungal intestinal microbiota analyses: Impact of storage conditions and DNA extraction protocols, PLoS ONE 2018;13(8):e0201174.
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2018Systematic gene overexpression in Candida albicans identifies a regulator of early adaptation to the mammalian gut, Cell. Microbiol. 2018 Jul;:e12890.
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2018Gene flow contributes to diversification of the major fungal pathogen Candida albicans, Nat Commun 2018 06;9(1):2253.
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2017The intraspecies diversity of C. albicans triggers qualitatively and temporally distinct host responses that determine the balance between commensalism and pathogenicity, Mucosal Immunol 2017 Feb;.
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2016Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the Candida albicans Diploid Genome, mBio 2016 10;7(5).
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